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The toxic effects of tetracycline exposure on the physiological homeostasis of the gut-liver axis in grouper

文献类型： 外文期刊

作者： Duan, Yafei 1 ; Yang, Yukai 1 ; Li, Hua 1 ; Zhang, Zhe 1 ; Chen, Xiaoying 3 ; Xiao, Meng 1 ; Nan, Yuxiu 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Key Lab South China Sea Fishery Resources Exploita, State Key Lab Mariculture Biobreeding & Sustainabl, South China Sea Fisheries Res Inst,Minist Agr & Ru, Guangzhou 510300, Peoples R China

2.Chinese Acad Fishery Sci, Shenzhen Base South China Sea Fisheries Res Inst, Shenzhen 518121, Peoples R China

3.Guangdong Acad Agr Sci, Minist Agr & Rural Affairs, Key Lab Anim Nutr & Feed Sci South China, Guangdong Key Lab Anim Breeding & Nutr,Inst Anim S, Guangzhou 510640, Peoples R China

4.Sanya Trop Fisheries Res Inst, Key Lab Efficient Utilizat & Proc Marine Fishery R, Sanya 572018, Peoples R China

关键词： Grouper; Antibiotics; Intestinal health; Metabolism; Physiology

期刊名称：ENVIRONMENTAL RESEARCH （ 影响因子：7.7； 五年影响因子：7.5 ）

ISSN： 0013-9351

年卷期： 2024 年 258 卷

页码：

收录情况： SCI

摘要： Antibiotic residues, such as tetracycline (TET), in aquatic environments have become a global concern. The liver and gut are important for immunity and metabolism in aquatic organisms. In this study, juvenile groupers were subjected to 1 and 100 mu g/L TET for 14 days, and the physiological changes of these fish were evaluated from the perspective of gut -liver axis. After TET exposure, the liver showed histopathology, lipid accumulation, and the elevated ALT activity. An oxidative stress response was induced in the liver and the metabolic pattern was disturbed, especially pyrimidine metabolism. Further, intestinal health was also affected, including the damaged intestinal mucosa, the decreased mRNA expression levels of tight junction proteins ( ZO-1 , Occludin , and Claudin3 ), along with the increased gene expression levels of inflammation ( IL-1 beta , IL -8 , TNF- alpha ) and apoptosis ( Casp-3 and p53 ). The diversity of intestinal microbes increased and the community composition was altered, and several beneficial bacteria ( Lactobacillus , Bacteroidales S24-7 group, and Romboutsia ) and harmful ( Aeromonas , Flavobacterium , and Nautella ) exhibited notable correlations with hepatic physiological indicators and metabolites. These results suggested that TET exposure can adversely affect the physiological homeostasis of groupers through the gut -liver axis.

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