Fisetin Delays Postovulatory Oocyte Aging by Regulating Oxidative Stress and Mitochondrial Function through Sirt1 Pathway
文献类型： 外文期刊
作者： Xing, Xupeng 1 ; Liang, Yalin 1 ; Li, Yanan 1 ; Zhao, Yaolu 1 ; Zhang, Yuxing 1 ; Li, Zheng 1 ; Li, Zicong 1 ; Wu, Zhenfang 1 ;
作者机构： 1.South China Agr Univ, Natl Engn Res Ctr Breeding Swine Ind, Guangzhou 510642, Peoples R China
2.South China Agr Univ, Coll Anim Sci, Gene Bank GuangDong Local Livestock & Poultry, Guangzhou 510642, Peoples R China
3.South China Agr Univ, State Key Lab Livestock & Poultry Breeding, Guangzhou 510642, Peoples R China
关键词： fisetin; postovulatory oocyte aging; oocyte quality; embryo development; Sirt1
期刊名称：MOLECULES （ 影响因子：4.6； 五年影响因子：4.9 ）
ISSN：
年卷期： 2023 年 28 卷 14 期
页码：
收录情况： SCI
摘要： The quality of oocytes determines the development potential of an embryo and is dependent on their timely fertilization after ovulation. Postovulatory oocyte aging is an inevitable factor during some assisted reproduction technology procedures, which results in poor fertilization rates and impairs embryo development. We found that fisetin, a bioactive flavonol contained in fruits and vegetables, delayed postovulatory oocyte aging in mice. Fisetin improved the development of aged oocytes after fertilization and inhibited the Sirt1 reduction in aged oocytes. Fisetin increased the GSH level and Sod2 transcription level to inhibit ROS accumulation in aged oocytes. Meanwhile, fisetin attenuated aging-induced spindle abnormalities, mitochondrial dysfunction, and apoptosis. At the molecular level, fisetin decreased aging-induced aberrant expression of H3K9me3. In addition, fisetin increased the expression levels of the mitochondrial transcription factor Tfam and the mitochondrial genes Co2 and Atp8 by upregulating Sirt1 in aged oocytes. Finally, inhibition of Sirt1 reversed the anti-aging effects of fisetin. Taken together, fisetin delayed postovulatory oocyte aging by upregulating Sirt1.
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