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Transcriptome and Metabolome Analyses Reveal the Mechanism of Corpus Luteum Cyst Formation in Pigs

文献类型： 外文期刊

作者： Dai, Jiage 1 ; Cai, Jiabao 1 ; Zhang, Taipeng 3 ; Pang, Mingyue 1 ; Xu, Xiaoling 1 ; Bai, Jiahua 1 ; Liu, Yan 1 ; Qin, Yusheng 1 ;

作者机构： 1.Beijing Acad Agr & Forestry Sci, Inst Anim Husb & Vet Med, Beijing 100097, Peoples R China

2.China Agr Univ, Coll Anim Sci & Technol, Beijing 100193, Peoples R China

3.Hebei Univ Engn, Coll Life Sci & Food Engn, Handan 056038, Peoples R China

4.Beijing Univ Agr, Anim Sci & Technol Coll, Beijing 102206, Peoples R China

关键词： luteal cyst; choline; Pi3k-Akt; MAPK; ALDH

期刊名称：GENES （ 影响因子：3.5； 五年影响因子：3.9 ）

ISSN：

年卷期： 2023 年 14 卷 10 期

页码：

收录情况： SCI

摘要： Corpus luteum cysts are a serious reproductive disorder that affects the reproductive performance of sows. In this study, transcriptome and metabolome datasets of porcine normal and cyst luteal granulosa cells were generated to explore the molecular mechanism of luteal cyst formation. We obtained 28.9 Gb of high-quality transcriptome data from luteum tissue samples and identified 1048 significantly differentially expressed genes between the cyst and normal corpus luteum samples. Most of the differentially expressed genes were involved in cancer and immune signaling pathways. Furthermore, 22,622 information-containing positive and negative ions were obtained through gas chromatography-mass spectrometry, and 1106 metabolites were successfully annotated. Important differentially abundant metabolites and pathways were identified, among which abnormal lipid and choline metabolism were involved in the formation of luteal cysts. The relationships between granulosa cells of luteal cysts and cancer, immune-related signaling pathways, and abnormalities of lipid and choline metabolism were elaborated, providing new entry points for studying the pathogenesis of porcine luteal cysts.

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