High Levels of Antibiotic Resistance in MDR-Strong Biofilm-Forming Salmonella Typhimurium ST34 in Southern China
文献类型： 外文期刊
作者： Gao, Yuan 1 ; Chen, Kaifeng 1 ; Lin, Runshan 1 ; Xu, Xuebin 7 ; Xu, Fengxiang 1 ; Lin, Qijie 1 ; Hu, Yaping 1 ; Zhang, Hongxia 1 ; Zhang, Jianmin 1 ; Liao, Ming 1 ; Qu, Xiaoyun 1 ;
作者机构： 1.Guangdong Lab Lingnan Modern Agr, Natl & Reg Joint Engn Lab Medicament Zoonoses Prev, Guangzhou 510642, Peoples R China
2.South China Agr Univ, Coll Vet Med, Key Lab Zoonoses, Minist Agr, Guangzhou 510642, Peoples R China
3.South China Agr Univ, Coll Vet Med, Key Lab Zoonoses Prevent & Control Guangdong Prov, Guangzhou 510642, Peoples R China
4.South China Agr Univ, Coll Vet Med, Anim Infect Dis Lab, Guangzhou 510642, Peoples R China
5.Univ Macau, Fac Hlth Sci, Macau 999078, Peoples R China
6.Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China
7.Shanghai Municipal Ctr Dis Control & Prevent, Dept Microbiol, Shanghai 200015, Peoples R China
8.Key Lab Livestock Dis Prevent Guangdong Prov YDWS2, Guangzhou 510642, Peoples R China
关键词： S. typhimurium; ST34; drug resistance; ACSSuT; biofilm
期刊名称：MICROORGANISMS （ 影响因子：4.5； 五年影响因子：4.8 ）
ISSN：
年卷期： 2023 年 11 卷 8 期
页码：
收录情况： SCI
摘要： Salmonella enterica subsp. enterica serovar Typhimurium (S. typhimurium) is an important zoonotic pathogen with important public health significance. To understand S. typhimurium's epidemiological characteristics in China, multi-locus sequence typing, biofilm-forming ability, antimicrobial susceptibility testing, and resistant genes of isolates from different regions and sources (human, food) were investigated. Among them, ST34 accounted for 82.4% (243/295), with ST19 ranking second (15.9%; 47/295). ST34 exhibited higher resistance levels than ST19 (p < 0.05). All colistin, carbapenem, and ciprofloxacin-resistant strains were ST34, as were most cephalosporin-resistant strains (88.9%; 32/36). Overall, 91.4% (222/243) ST34 isolates were shown to have multidrug resistance (MDR), while 53.2% (25/47) ST19 isolates were (p < 0.05). Notably, 97.8% (45/46) of the MDR-ACSSuT (resistance to Ampicillin, Chloramphenicol, Streptomycin, Sulfamethoxazole, and Tetracycline) isolates were ST34, among which 69.6% (32/46) of ST34 isolates were of human origin, while 30.4% (14/46) were derived from food (p < 0.05). Moreover, 88.48% (215/243) ST34 showed moderate to strong biofilm-forming ability compared with 10.9% (5/46) ST19 isolates (p < 0.01). This study revealed the emergence of high-level antibiotic resistance S. typhimurium ST34 with strong biofilm-forming ability, posing concerns for public health safety.
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