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Synthesis, antifungal activity and mechanism of action of novel chalcone derivatives containing 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole

文献类型： 外文期刊

作者： Zhan, Wenliang 1 ; Zhou, Ran 1 ; Mao, Piao 1 ; Yuan, Chunmei 1 ; Zhang, Tao 1 ; Liu, Yi 1 ; Tian, Jiao 1 ; Wang, Hua 4 ; Xue, Wei 1 ;

作者机构： 1.Guizhou Univ, State Key Lab Breeding Base Green Pesticide & Agr, Guiyang 550025, Peoples R China

2.Guizhou Univ, Key Lab Green Pesticide & Agr Bioengn, Minist Educ, Guiyang 550025, Peoples R China

3.Guizhou Univ, Res & Dev Ctr Fine Chem, Guiyang 550025, Peoples R China

4.Hubei Acad Agr Sci, Inst Plant Protect & Soil Fertil, Wuhan 430064, Peoples R China

关键词： Chalcone; 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole; Antifungal activity; Mechanism study

期刊名称：MOLECULAR DIVERSITY （ 影响因子：3.8； 五年影响因子：3.3 ）

ISSN： 1381-1991

年卷期： 2023 年

页码：

收录情况： SCI

摘要： A series of chalcone derivatives containing 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole was designed and synthesized. Structures of all compounds were characterized by H-1 NMR, C-13 NMR, F-19 NMR, and HRMS. The biological activities of the compounds were determined with the mycelial growth rate method, and further studies showed that some compounds had good antifungal activities at the concentration of 100 mu g/mL. The EC50 value of compound L31 was 15.9 mu g/mL against Phomopsis sp., which were better than that of azoxystrobin (EC50 value was 69.4 mu g/mL). In addition, the mechanism of action of compound L31 shown that compound can affect mycelial growth by disrupting membrane integrity against Phomopsis sp., and that the higher the concentration of the compound is, the greater the disruption of membrane integrity is. [GRAPHICS] .

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