文献类型： 外文期刊

作者： Cui, Boya ¹ ; Liu, Lanying ² ; Shi, Tao ¹ ; Yin, Min ¹ ; Feng, Xu ¹ ; Shan, Yu ¹ ;

作者机构： 1.Jiangsu Prov & Chinese Acad Sci, Nanjing Bot Garden, Inst Bot, Jiangsu Key Lab Res & Utilizat Plant Resources,Mem, Nanjing 210014, Peoples R China

2.Ningxia Acad Agr & Forestry Sci, Inst Wolfberry Engn Technol, Natl Wolfberry Engn Res Ctr, Yinchuan 750002, Peoples R China

关键词： anthocyanins; spermidines; oxidative stress; cognitive impairment; cellular senescence

期刊名称：MOLECULES （ 影响因子：4.6； 五年影响因子：4.9 ）

ISSN：

年卷期： 2023 年 28 卷 22 期

页码：

收录情况： SCI

摘要： Aging and age-related diseases are important study topics due to their associations with progressive physiological damage to genes, cells, tissues, and the entire organism, which ultimately affects the functional efficiency of organs. Lycium ruthenicum Murr. is a functional food that is known for its high contents of anthocyanins and spermidines, both of which have been demonstrated to have positive effects on anti-aging activity and anti-oxidation. In this study, we used HPLC-MS to analyze the constituents of L. ruthenicum Murr. Extract (LRM) and investigated their potential mechanism for exerting antioxidative effects in D-galactose (D-Gal) aging model mice. LRM (25 mg/kg, 50 mg/kg, and 100 mg/kg) improved cognitive function in D-Gal-treated mice, as shown by reduced escape latencies and increased platform crossings in behavioral tests. We measured the contents of lipid peroxidation (LPO) and malondialdehyde (MDA) and the enzyme activities of the antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in mice serum and brain after 6 weeks of D-Gal treatment. LRM decreased the contents of LPO and MDA and increased the enzyme activities of SOD and GSH-Px, indicating the protection effect of LRM against D-Gal-induced oxidative stress. Additionally, LRM can inhibit oxidative stress in cells by reducing intracellular ROS levels and restoring mitochondrial membrane potential, thereby inhibiting paraquat (PQ)-induced cellular senescence and delaying cell aging. Therefore, LRM has the potential to be a healthcare product for the treatment of age-related diseases.