文献类型： 外文期刊

作者： Liu, Lanying ¹ ; Guan, Fuqin ² ; Chen, Yu ² ; Wang, Fan ² ; Chen, Pengxu ² ; Yin, Min ² ; Wang, Bi ² ; Li, Linwei ² ; Wang, Qizhi ² ; Gu, Yonghua ² ; Feng, Xu ² ;

作者机构： 1.Ningxia Acad Agr & Forestry Sci, Natl Wolfberry Engn Technol Res Ctr, Yinchuan 750002, Ningxia, Peoples R China

2.Jiangsu Prov & Chinese Acad Sci, Jiangsu Prov Engn Res Ctr Ecocultivat & High Valu, Inst Bot, Jiangsu Key Lab Res & Utilizat Plant Resources, Nanjing 210014, Peoples R China

3.Nanjing Univ Chinese Med, Coll Pharm, Nanjing 210023, Peoples R China

关键词： Atractylodes lancea; sesquiterpenoid glycosides; secoatractylohexone A; network pharmacology

期刊名称：MOLECULES （ 影响因子：4.927； 五年影响因子：5.11 ）

ISSN：

年卷期： 2022 年 27 卷 18 期

页码：

收录情况： SCI

摘要： Secoatractylohexone A (1), an unprecedented secoguaiane lactone glycoside featuring 6/7 cores and dihydroxy-9-guaine-3-one 11-O-beta-d-glucopyranoside (2), a 9,10-unsaturated guaiene-type glycoside possessing an uncommon scaffold, were isolated from the water-soluble portion of the ethanolic extract of Atractylodes lancea rhizomes together with five known compounds (3-7). The structures of 1 and 2 were elucidated on the basis of extensive spectroscopic data and application of the CD technique. The potential biological activities of secoatractylohexone A were predicted by network pharmacology in silico, the result of which indicated that secoatractylohexone A may be used to treat type II diabetes.