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BmMD-2A responds to 20-hydroxyecdysone and regulates Bombyx mori silkworm innate immunity in larva-to-pupa metamorphosis

文献类型： 外文期刊

作者： Zhang, Ruonan 1 ; Chen, Xue 1 ; Wang, Yuan 1 ; Bai, Xu 1 ; Yang, Qiong 3 ; Zhong, Yangjin 1 ; Yu, Xiao-Qiang 4 ; Jin, Fengliang 2 ; Yang, Wanying 1 ;

作者机构： 1.South China Agr Univ, Coll Anim Sci, Lab Insect Mol Biol & Biotechnol, Guangdong Lab Lingnan Modern Agr,Guangdong Prov K, Guangzhou 510642, Peoples R China

2.South China Agr Univ, Coll Plant Protect, Guangdong Lab Biopesticide Creat & Applicat Guang, Guangzhou 510642, Peoples R China

3.Guangdong Acad Agr Sci, Sericultural & Agrifood Res Inst, Guangzhou, Peoples R China

4.South China Normal Univ, Sch Life Sci, Inst Insect Sci & Technol, Guangdong Prov Key Lab Insect Dev Biol & Appl Tec, Guangzhou, Peoples R China

关键词： AMPs; BmMD-2A; 20E; innate immune; metamorphosis

期刊名称：INSECT SCIENCE （ 影响因子：3.605； 五年影响因子：3.323 ）

ISSN： 1672-9609

年卷期：

页码：

收录情况： SCI

摘要： 20E-hydroxyecdysone (20E) plays important roles in larval molting and metamorphosis in insects and is also involved in the insect innate immune response. Insect metamorphosis is a highly successful strategy for environmental adaptation and is the most vulnerable stage during which the insect is susceptible to various pathogens. 20E regulates a series of antimicrobial peptides (AMPs) through the immunodeficiency (IMD) pathway activation in Drosophila; nevertheless, whether other immune pathways are involved in 20E-regulated insect immunity is unknown. Our previous studies showed that BmMD-2A is a member of the MD-2-related lipid recognition (ML) family of proteins that are involved in the Bombyx mori innate immunity Toll signaling pathway. In this study, we further demonstrate that BmMD-2A is also positively regulated by 20E, and the BmMD-2A neutralization experiment suggested that 20E activates some downstream immune effect factors, the AMP genes against Escherichia coli and Staphylococcus aureus, through the regulation of BmMD-2A in larval metamorphosis, implying that B. mori may use the Toll-ML signaling pathway to maintain innate immune balance in the larval-pupal metamorphosis stage, which is a different innate immunity pathway regulated by 20E compared to the IMD pathway in Drosophila.

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