您好，欢迎访问内蒙古农牧业科学院 机构知识库！
内蒙古农牧业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Anti-inflammatory effects of the prostaglandin D-2/prostaglandin DP1 receptor and lipocalin-type prostaglandin D-2 synthase/prostaglandin D-2 pathways in bacteria-induced bovine endometrial tissue

文献类型： 外文期刊

作者： Wu, Jindi 1 ; Bai, Fan 4 ; Mao, Wei 2 ; Liu, Bo 2 ; Yang, Xiaolin 2 ; Zhang, Jing 2 ; Li, Tingting 2 ; Borjigin, Gerelt 1 ; Cao, Jinshan 2 ;

作者机构： 1.Inner Mongolia Agr Univ, Coll Food Sci & Engn, Hohhot 010018, Peoples R China

2.Inner Mongolia Agr Univ, Coll Vet Med, Lab Vet Pharmacol, Hohhot 010018, Peoples R China

3.Minist Agr, Key Lab Clin Diag & Treatment Tech Anim Dis, Hohhot 010018, Peoples R China

4.Inner Mongolia Acad Agr & Anim Husb Sci, Vet Res Inst, Hohhot 010031, Peoples R China

关键词： DP1 receptor; Escherichia coli; Staphylococcus aureus; anti-inflammatory effects; bovine endometrial tissue; L-PGDS; PGD(2) pathway

期刊名称：VETERINARY RESEARCH （ 影响因子：3.829； 五年影响因子：4.269 ）

ISSN： 0928-4249

年卷期： 2022 年 53 卷 1 期

页码：

收录情况： SCI

摘要： Dairy cows often develop different degrees of endometritis after calving and this is attributed to pathogenic bacterial infections such as by Escherichia coli and Staphylococcus aureus. Infection of the bovine endometrium causes tissue damage and increases the expression of prostaglandin D-2 (PGD(2)), which exerts anti-inflammatory effects on lung inflammation. However, the roles of PGD(2) and its DP1 receptor in endometritis in cows remain unclear. Here, we examined the anti-inflammatory roles of the lipocalin-type prostaglandin D-2 synthase (L-PGDS)/PGD(2) and DP1 receptor regulatory pathways in bovine endometritis. We evaluated the regulatory effects of PGD(2) on inflammation and tissue damage in E. coli- and S. aureus-infected bovine endometrial cells cultured in vitro. We found that the secretion of pro-inflammatory cytokines interleukin (IL)-6, IL-1 beta, and tumour necrosis factor (TNF)-alpha as well as expression of matrix metalloproteinase (MMP)-2, platelet-activating factor receptor (PAFR), and high mobility group box (HMGB)-1 were suppressed after DP1 receptor agonist treatment. In contrast, IL-6, IL-1 beta, and TNF-alpha release and MMP-2, PAFR, and HMGB-1 expression levels were increased after treatment of bovine endometrial tissue with DP1 receptor antagonists. DP1-induced anti-inflammatory effects were dependent on cellular signal transduction. The L-PGDS/PGD(2) pathway and DP1 receptor induced anti-inflammatory effects in bovine endometrium infected with S. aureus and E. coli by inhibiting the mitogen-activated protein kinase and nuclear factor-kappa B signalling pathways, thereby reducing tissue damage. Overall, our findings provide important insights into the pathophysiological roles of PGD(2) in bovine endometritis and establish a theoretical basis for applying prostaglandins or non-steroidal anti-inflammatory drugs for treating endometrial inflammatory infertility in bovines.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：内蒙古农牧业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台