Six Undescribed Capnosane-Type Macrocyclic Diterpenoids from South China Sea Soft Coral Sarcophyton crassocaule: Structural Determination and Biological Evaluation
文献类型： 外文期刊
作者： Peng, Hanyang 1 ; Zeng, Yanbo 1 ; Wang, Hao 1 ; Chang, Wenjun 1 ; Chen, Huiqin 1 ; Zhou, Fengjuan 3 ; Dai, Haofu 1 ; Wang, Xiachang 3 ;
作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Prov Key Lab Funct Components Res & Utiliza, Haikou 571101, Peoples R China
2.Hainan Inst Trop Agr Resources, Key Lab Biol & Genet Resources Trop Crops Hainan P, Haikou 571101, Peoples R China
3.Nanjing Univ Chinese Med, Jiangsu Key Lab Funct Subst Chinese Med, Nanjing 210023, Peoples R China
4.Chinese Acad Trop Agr Sci, Zhanjiang Expt Stn, Zhanjiang 524013, Peoples R China
关键词： soft coral; Sarcophyton crassocaule; cembranoids; capnosane-type macrocyclic diterpenes; absolute configuration; anti-inflammation
期刊名称：MARINE DRUGS （ 影响因子：5.4； 五年影响因子：5.5 ）
ISSN：
年卷期： 2023 年 21 卷 12 期
页码：
收录情况： SCI
摘要： Six undescribed capnosane-type macrocyclic diterpenes sarcocrassolins A-F (1-6) and one related known analog pavidolide D (7) were isolated from Sarcophyton crassocaule, a soft coral collected off the Nansha Islands, in the South China Sea. Their complete structures, relative configurations and absolute configurations were established through comprehensive spectroscopic analysis, quantum mechanical nuclear magnetic resonance (QM-NMR) and single-crystal X-ray diffraction. Sarcocrassolins D (4) and E (5) showed inhibitory activity against lipopolysaccharide (LPS)-stimulated inflammatory responses in RAW264.7 cells with IC50 values of 76.8 +/- 8.0 mu M and 93.0 +/- 3.8 mu M, respectively.
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