Betaine improves appetite regulation and glucose-lipid metabolism in mandarin fish (Siniperca chuatsi) fed a high-carbohydrate-diet by regulating the AMPK/mTOR signaling
文献类型： 外文期刊
作者： Li, Hongyan 1 ; Zeng, Yanzhi 1 ; Wang, Guangjun 1 ; Zhang, Kai 1 ; Gong, Wangbao 1 ; Li, Zhifei 1 ; Tian, Jingjing 1 ; Xia, Yun 1 ; Xie, Wenping 1 ; Xie, Jun 1 ; Xie, Shouqi 2 ; Yu, Ermeng 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Pearl River Fisheries Res Inst, Key Lab Trop & Subtrop Fishery Resource Applicat &, Guangzhou 510380, Peoples R China
2.Chinese Acad Sci, Key Lab Breeding Biotechnol & Sustainable Aquacult, Beijing, Peoples R China
3.Fujian Tianma Sci & Technol Grp Co Ltd, Fujian Prov Key Lab Special Aquat Formula Feed, Fuqing 350308, Peoples R China
4.Shanghai Ocean Univ, Natl Demonstrat Ctr Expt Fisheries Sci Educ, Shanghai 201306, Peoples R China
关键词： Mandarin fish; Betaine; AMPK/mTOR; Appetite regulation; Glucose-lipid metabolism
期刊名称：HELIYON （ 影响因子：4.0； 五年影响因子：4.1 ）
ISSN：
年卷期： 2024 年 10 卷 7 期
页码：
收录情况： SCI
摘要： Diets with high carbohydrate (HC) was reported to have influence on appetite and intermediary metabolism in fish. To illustrate whether betaine could improve appetite and glucose-lipid metabolism in aquatic animals, mandarin fish (Siniperca chuatsi) were fed with the HC diets with or without betaine for 8 weeks. The results suggested that betaine enhanced feed intake by regulating the hypothalamic appetite genes. The HC diet-induced downregulation of AMPK and appetite genes was also positively correlated with the decreased autophagy genes, suggesting a possible mechanism that AMPK/mTOR signaling might regulate appetite through autophagy. The HC diet remarkably elevated transcriptional levels of genes related to lipogenesis, while betaine alleviated the HC-induced hepatic lipid deposition. Additionally, betaine supplementation tended to store the energy storage as hepatic glycogen. Our findings proposed the possible mechanism for appetite regulation through autophagy via AMPK/mTOR, and demonstrated the feasibility of betaine as an aquafeed additive to regulate appetite and intermediary metabolism in fish.
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