Autophagy enhances the antibacterial response in Macrobrachium rosenbergii by modulating cellular metabolism and immune pathways
文献类型： 外文期刊
作者： Wang, Feifei 1 ; Liu, Yang 1 ; Wen, Jing 1 ; Tan, Aiping 1 ; Deng, Yuting 1 ; Wang, Ling 2 ; Gong, Hua 1 ; Lai, Yingtiao 1 ; Huang, Zhibin 1 ; Zhao, Fei 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Pearl River Fisheries Res Inst, Key Lab Fishery Drug Dev,Minist Agr & Rural Affair, Guangdong Prov Key Lab Aquat Anim Immunol & Sustai, Guangzhou 510380, Peoples R China
2.Zhaoqing Branch Ctr, Guangdong Lab Lingnan Modern Agr Sci & Technol, Zhaoqing 526238, Peoples R China
关键词： Macrobrachium rosenbergii; Aeromonas hydrophila; Autophagy; Metabolism; Immune response
期刊名称：FISH & SHELLFISH IMMUNOLOGY （ 影响因子：3.9； 五年影响因子：4.2 ）
ISSN： 1050-4648
年卷期： 2025 年 161 卷
页码：
收录情况： SCI
摘要： Autophagy plays a crucial role in innate and adaptive immunity against invading microorganisms. However, the mechanism underlying autophagy in Macrobrachium rosenbergii remains largely unknown. Here, we demonstrate that Aeromonas hydrophila activates autophagy in M. rosenbergii, according to Western blot, qRT-PCR, and transmission electron microscopy observations. Rapamycin treatment to activate autophagy in M. rosenbergii followed by stimulation with A. hydrophila significantly decreased the A. hydrophila OmpA copy number in the gills of M. rosenbergii. Furthermore, high-throughput RNA-seq analysis of M. rosenbergii gills treated with rapamycin revealed 1684 upregulated and 1500 downregulated differentially expressed genes (DEGs), most of which regulate metabolic pathways. A comprehensive joint analysis of the two transcriptomic databases for A. hydrophila infection and rapamycin treatment identified 15 upregulated and 25 downregulated DEGs, respectively. These genes enhance the immune defense of M. rosenbergii by negatively regulating metabolic pathways and promoting immune pathways. Our results provide a theoretical basis for further exploration of the antibacterial mechanism of M. rosenbergii.
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