Alkaline Extracted Purified Polysaccharide from Hulless Barley Grass and Its Proliferation Inhibitory Effect Against Cancer Cells
文献类型： 外文期刊
作者： Xu, Yijuan 1 ; Hua, Weifeng 1 ; Xu, Haoran 1 ; Corke, Harold 2 ; Huang, Wuyang 4 ; Sui, Zhongquan 1 ;
作者机构： 1.Shanghai Jiao Tong Univ, Sch Agr & Biol, Dept Food Sci & Technol, Shanghai 200240, Peoples R China
2.Guangdong Technion Israel Inst Technol, Biotechnol & Food Engn Program, Shantou 515063, Peoples R China
3.Technion Israel Inst Technol, Fac Biotechnol & Food Engn, IL-3200003 Haifa, Israel
4.Jiangsu Acad Agr Sci, Inst Agroprod Proc, Nanjing 210014, Peoples R China
关键词： alkaline extracted polysaccharide; cancer cells; cell proliferation inhibition; chemical characterization; hulless barley grass
期刊名称：STARCH-STARKE （ 影响因子：2.3； 五年影响因子：2.6 ）
ISSN： 0038-9056
年卷期： 2023 年
页码：
收录情况： SCI
摘要： Hulless barley (HB) grass is a potential resource of functional food. In this study, the proliferation inhibitory effect against cancer cells of an alkaline extracted polysaccharide (APP) from HB grass (HBG) is analyzed. The yield of crude alkaline extracted polysaccharide (APC) reaches 15.1%. After purification, the purity and polydispersity index (PDI) of the APP are 98.3% and 1.38, respectively. The molecular weight of APP is 5.1 x 10(5) Da, whereas the number-average molecular weight of APP is 3.7 x 10(5) Da. APP is composed of arabinose (37.8%), xylose (41.3%), glucose (4.6%), and galactose (16.3%). According to the infrared spectral analysis, APP is found to contain beta-glycosidic bonds. Moreover, APP possesses significant cell proliferation inhibitory effects against various cancer cell lines, such as 4T1, HT29, Caco-2, and CT26.WT in a dose-dependent manner. Notably, the IC50 value of 4T1 reaches 7.56 mg mL(-1), which indicates that APP from HBG has a potential anti-cancer effect in vitro. It may be further investigated as an ingredient or nutraceutical for development and utilization in functional foods to prevent or treat cancer and related diseases.
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