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Genome-Wide Association Study of Egg Production Traits in Shuanglian Chickens Using Whole Genome Sequencing

文献类型： 外文期刊

作者： Fu, Ming 1 ; Wu, Yan 1 ; Shen, Jie 1 ; Pan, Ailuan 1 ; Zhang, Hao 1 ; Sun, Jing 1 ; Liang, Zhenhua 1 ; Huang, Tao 1 ; Du, Jinping 1 ; Pi, Jinsong 1 ;

作者机构： 1.Hubei Acad Agr Sci, Inst Anim Husb & Vet, Wuhan 430064, Peoples R China

2.Hubei Acad Agr Sci, Hubei Key Lab Anim Embryo & Mol Breeding, Wuhan 430064, Peoples R China

关键词： Shuanglian chickens; egg production trait; GWAS; whole genome sequencing

期刊名称：GENES （ 影响因子：3.5； 五年影响因子：3.9 ）

ISSN：

年卷期： 2023 年 14 卷 12 期

页码：

收录情况： SCI

摘要： Egg production is the most important economic trait in laying hens. To identify molecular markers and candidate genes associated with egg production traits, such as age at first egg (AFE), weight at first egg (WFE), egg weight (EW), egg number (EN), and maximum consecutive egg laying days (MCD), a genome-wide analysis by whole genome sequencing was performed in Shuanglian chickens. Through whole genome sequencing and quality control, a total of 11,006,178 SNPs were obtained for further analysis. Heritability estimates ranged from moderate to high for EW (0.897) and MCD (0.632), and from low to moderate (0.193 similar to 0.379) for AFE, WFE, and EN. The GWAS results showed 11 genome-wide significant SNPs and 23 suggestive significant SNPs were identified to be associated with EN, MCD, WFE, and EW. Linkage disequilibrium analysis revealed twenty-seven SNPs associated with EN were located in a 0.57 Mb region on GGA10, and clustered into five blocks. Through functional annotation, three candidate genes NEO1, ADPGK, and CYP11A1, were identified to be associated with EN, while the S1PR4, LDB2, and GRM8 genes was linked to MCD, WFE, and EW, respectively. These findings may help us to better understand the molecular mechanisms underlying egg production traits in chickens and contribute to genetic improvement of these traits.

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