Polyketides with IDH1 R132h and PTP1B inhibitory activities from the desert-plant-derived fungus Alternaria sp. HM 134
文献类型： 外文期刊
作者： Li, Zhuang 1 ; Meng, Lu 1 ; Ma, Qingyun 2 ; Wang, Zhen 3 ; Zhao, Youxing 2 ; Luo, Duqiang 1 ;
作者机构： 1.Hebei Univ, Coll Life Sci, Key Lab Med Chem & Mol Diag, Minist Educ, Baoding, Peoples R China
2.CATAS, Hainan Inst Trop Agr Resources, Inst Trop Biosci & Biotechnol, Hainan Key Lab Res & Dev Nat Prod Li Folk Med, Haikou, Peoples R China
3.Hebei Univ Engn, Affiliated Hosp, Med Coll, Handan, Peoples R China
关键词： desert-plant-derived fungus; polyketides; protein tyrosine phosphatase inhibitory activities; isocitrate dehydrogenase inhibitory activities; Alternaria sp
期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：6.064； 五年影响因子：6.843 ）
ISSN：
年卷期： 2022 年 13 卷
页码：
收录情况： SCI
摘要： Five new polyketides named alternafurones A (1) and B (2), alternapyrones M-O (3-5), together with fourteen known ones (6-19), were isolated from the desert-plant-derived fungus Alternaria sp. HM 134. The structures of the new compounds were elucidated from spectroscopic data and ECD spectroscopic analyses. Alternafurones A and B represent polyketides with an unprecedented 6/5/6 skeleton core. Compounds 1, 2 and 4 showed definite inhibitory activities against isocitrate dehydrogenase 1 gene (IDH1 R132h) with IC50 values of 29.38, 19.41 and 14.14 mu g/ml, respectively. Seven compounds (6, 7, 9-12, 14) showed potent protein tyrosine phosphatase 1B (PTP1B) inhibitory activity with IC50 values ranging from 0.97 mu g/ml to 89.80 mu g/ml.
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