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Bioactive chemical constituents from the marine-derived fungus Cladosporium sp. DLT-5

文献类型： 外文期刊

作者： Dai, Luting 1 ; Xie, Qingyi 2 ; Guo, Jiaocen 2 ; Ma, Qingyun 2 ; Yang, Li 2 ; Yuan, Jingzhe 2 ; Dai, Haofu 2 ; Yu, Zhifang 1 ; Zhao, Youxing 2 ;

作者机构： 1.Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing 210095, Peoples R China

2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Res & Dev Nat Prod Li Folk Med Hainan Prov, Haikou 571101, Peoples R China

3.Hainan Acad Trop Agr Resource, Haikou 571101, Peoples R China

关键词： Cladosporium sp.; marine-derived fungus; neuroprotective effects; protein tyrosine phosphatase 1B (PTP1B); antifungal activity

期刊名称：JOURNAL OF OCEANOLOGY AND LIMNOLOGY （ 影响因子：1.6； 五年影响因子：1.6 ）

ISSN： 2096-5508

年卷期： 2024 年

页码：

收录情况： SCI

摘要： A new isochromanone, cladosporinisochromanone (1), accompanied by 15 known compounds (2-16) were obtained from secondary metabolites produced by marine-derived fungus Cladosporium sp. DLT-5. NMR and HRESIMS spectra elucidation determined the planar structure of 1. Subsequent electronic circular dichroism (ECD) experiment assigned the absolute configuration of 1. Compounds 1, 2, 4-6, and 10 displayed different degrees of neuroprotective activities on human neuroblastoma cells SH-SY5Y. Five compounds (1, 3-5, and 13) emerged resistance to protein tyrosine phosphatase 1B (PTP1B), further kinetic analysis and molecular docking study indicated that the most potent compound 13 (IC50 value of 10.74 +/- 0.61 mu mol/L) was found as a noncompetitive inhibitor for PTP1B. Surface plasmon resonance (SPR) and molecular docking studies also demonstrated the interaction between compound 12 and Niemann-Pick C1 Like 1 (NPC1L1), which has been identified as significant therapeutic target for hypercholesteremia. In addition, compounds 3, 6, and 14 showed attractive inhibitory activity against the phytopathogenic fungi: Colletotrichum capsici. Therefore, library of Cladosporium metabolites is enriched and new active uses of known compounds are explored.

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