Analysis of metagenome and metabolome disclosed the mechanisms of Dendrobium officinale polysaccharide on DSS-induced ulcerative colitis-affected mice
文献类型： 外文期刊
作者： Zeng, Xiaona 1 ; Tang, Shengqiu 1 ; Dong, Xiaoying 1 ; Dong, Mengyue 2 ; Shao, Runlin 2 ; Liu, Ruiheng 2 ; Li, Tong 2 ; Zhang, Xinheng 2 ; Wong, Yung Hou 7 ; Xie, Qingmei 2 ;
作者机构： 1.Shaoguan Univ, Guangdong Prov Key Lab Utilizat & Conservat Food &, Shaoguan 512005, Peoples R China
2.South China Agr Univ, Coll Anim Sci, State Key Lab Swine & Poultry Breeding Ind, Guangdong Prov Lab Lingnan Modern Agr Sci & Techno, Guangzhou 510642, Peoples R China
3.South China Agr Univ, Coll Anim Sci, Heyuan Branch, Guangdong Prov Lab Lingnan Modern Agr Sci & Techno, Guangzhou 510642, Peoples R China
4.Shaoguan Univ, Henry Fok Sch Biol & Agr, Shaoguan 512005, Peoples R China
5.South China Agr Univ, Coll Anim Sci, Guangdong Prov Key Lab Agroanim Genom & Mol Breed, Guangzhou 510642, Peoples R China
6.Guangdong Engn Res Ctr Vector Vaccine Anim Virus, Guangzhou 510642, Peoples R China
7.Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Peoples R China
8.Hong Kong Univ Sci & Technol, Biotechnol Res Inst, Hong Kong, Peoples R China
关键词： Dendrobium officinale polysaccharide; Ulcerative colitis (UC); Metagenome; Metabolome
期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：7.7； 五年影响因子：7.7 ）
ISSN： 0141-8130
年卷期： 2024 年 277 卷
页码：
收录情况： SCI
摘要： Currently, there is no known cause for ulcerative colitis (UC), an inflammatory bowel disease that is difficult to treat. This assay aimed to investigate the protective effects and mechanisms of Dendrobium officinale polysaccharide (DOP) in mice with acute UC induced by dextran sulphate sodium (DSS). We found that DOP could improve weight loss, decrease the disease activity index (DAI), and regulate the release of interleukin 2 (IL-2), IL4, IL-6, and IL-10 in DSS-induced acute UC mice. Additionally, DOP preserved the integrity of the intestinal barrier in UC mice by increasing goblet cell density and maintaining tight junctions. DOP significantly enhanced total antioxidant capacity (T-AOC), and reduced glutathione (GSH), nitric oxide (NO), and malondialdehyde (MDA) levels in the bloodstream. In terms of serum biochemistry, DOP markedly elevated levels of bilirubin (BIL), alkaline phosphatase (ALP), total bile acid (TBA), creatinine (Crea), and creative kinase isoenzyme (CKMB). Furthermore, DOP increased the relative abundance of Lactobacillales. DOP also improved intestinal health and stimulated the synthesis of potent anti-inflammatory and antiviral substances by regulating the metabolism of purines, prostaglandins, and leukotrienes. Therefore, DOP can be considered a functional dietary supplement for the treatment of UC, as it improves the condition of DSS-induced UC mice.
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