文献类型： 外文期刊

作者： Ji, Zhong-Hao ¹ ; Xie, Wen-Yin ¹ ; Zhao, Pei-Sen ¹ ; Wu, Hong-Yu ¹ ; Ren, Wen-Zhi ¹ ; Hu, Jin-Ping ¹ ; Gao, Wei ⁴ ; Yuan, Bao ¹ ; Cacciola, Nunzio Antonio ¹ ; Borrelli, Francesca ¹ ; De Cicco, Paola ¹ ;

作者机构： 1.Jilin Univ, Coll Anim Sci, Dept Lab Anim, Changchun 130062, Peoples R China

2.Changzhi Med Coll, Dept Basic Med, Changzhi 046000, Peoples R China

3.Jilin Acad Agr Sci, Jilin 132101, Peoples R China

4.Jilin Univ, Changchun Natl Expt Anim Ctr, Changchun 130062, Peoples R China

关键词： IBD; oats; peptides; Keap1-Nrf2; gut bacteria

期刊名称：NUTRIENTS （ 影响因子：5.9； 五年影响因子：6.6 ）

ISSN：

年卷期： 2023 年 15 卷 24 期

页码：

收录情况： SCI

摘要： The prevalence of inflammatory bowel disease (IBD) is progressively rising each year, emphasizing the significance of implementing rational dietary interventions for disease prevention. Oats, being a staple agricultural product, are abundant in protein content. This study aimed to investigate the protective effects and underlying mechanisms of oat peptides (OPs) in a mouse model of acute colitis induced by dextran sulfate sodium salt (DSS) and a Caco-2 cell model. The findings demonstrated that intervention with OPs effectively mitigated the symptoms associated with DSS-induced colitis. The physicochemical characterization analysis demonstrated that the molecular weight of the OPs was predominantly below 5 kDa, with a predominant composition of 266 peptides. This study provides further evidence of the regulatory impact of OPs on the Keap1-Nrf2 signaling axis and elucidates the potential role of WGVGVRAERDA as the primary bioactive peptide responsible for the functional effects of OPs. Ultimately, the results of this investigation demonstrate that OPs effectively mitigate DSS-induced colitis by preserving the integrity of the intestinal barrier and modulating the Keap1-Nrf2 axis. Consequently, these findings establish a theoretical foundation for the utilization of OPs as dietary supplements to prevent the onset of IBD.