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Exosomes in Mastitis-Research Status, Opportunities, and Challenges

文献类型： 外文期刊

作者： Ji, Zhong-Hao 1 ; Ren, Wen-Zhi 1 ; Wu, Hong-Yu 1 ; Zhang, Jia-Bao 1 ; Yuan, Bao 1 ;

作者机构： 1.Jilin Univ, Coll Anim Sci, Dept Lab Anim, Changchun 130062, Peoples R China

2.Changzhi Med Coll, Dept Basic Med, Changzhi 046000, Peoples R China

3.Jilin Acad Agr Sci, Jilin 132101, Jilin, Peoples R China

关键词： mastitis; exosomes; miRNA; biomarkers; drug delivery vehicles; intercellular communication

期刊名称：ANIMALS （ 影响因子：3.231； 五年影响因子：3.312 ）

ISSN： 2076-2615

年卷期： 2022 年 12 卷 20 期

页码：

收录情况： SCI

摘要： Simple Summary Mastitis is one of the most common diseases in dairy cows, causing large economic losses. The development of early diagnostic markers for mastitis and the elucidation of pathogenesis are of great importance for the prevention and treatment of mastitis. Exosomes are extracellular vesicles secreted by cells that contain cargoes of nucleic acids and proteins that reflect the state of the cell and mediate intercellular communication. In this review, we introduce the knowledge of exosomes, review the current status of exosome research related to mastitis, and look forward to the application of exosomes in the diagnosis and treatment of mastitis and in performing disease mechanism elucidation. Mastitis, which affects milk quality and yield, is one of the most common diseases in dairy cows, causing large economic losses. Cow mastitis is classified into clinical and subclinical types. Subclinical mastitis presents without obvious lesions in the udder or noticeable change in milk samples, indicating persistent chronic infection that is difficult to detect and treat. Therefore, finding specific biomarkers is of great significance for the early diagnosis and treatment of subclinical mastitis. As mediators of intercellular communication, exosomes have been shown to be extensively involved in various physiological and pathological processes in the body. Exosomes in milk, blood, and cell supernatant can carry stable cell source-specific nucleic acids, proteins, and metabolites. Hence, exosomes show great application prospects for early diagnosis, targeted therapy, and disease mechanism analysis. In this review, we summarize the biogenesis, biological functions, and methods of isolating and identifying exosomes and review the current status of exosome research related to mastitis. Finally, in view of the application of exosomes to diagnose, treat, and perform disease mechanism analysis in mastitis, deficiencies in recent research on mastitis exosomes are described, and the direction of future exosome research efforts in mastitis is proposed.

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