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CpG oligodeoxynucleotides augment the immune responses of piglets to swine Pasteurella multocida living vaccine in vivo

文献类型： 外文期刊

作者： Zhang Linghua 1 ; Tian Xingshan 2 ; Zhou Fengzhen 2 ;

作者机构： 1.S China Agr Univ, Coll Life Sci, Guangzhou 510642, Guangdong, Peoples R China

2.S China Agr Univ, Coll Life Sci, Guangzhou 510642, Guangdong, Peoples R China; Guangdong Acad Agr Sci, Guangzhou 510640, Guangdong, Peoples R China

关键词： Animals;Bacterial Vaccines immunology;Cell Proliferation;CpG Islands genetics immunology;Cytokines blood;Dose-Response Relationship;Drug;Immunoglobulin G blood;Leukocytes;Mononuclear physiology;Pasteurella multocida immunology;Swine;Swine Diseases immunology microbiology prevention & control;Time Factors

期刊名称：RESEARCH IN VETERINARY SCIENCE （ 影响因子：2.534； 五年影响因子：2.382 ）

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收录情况： SCI

摘要： Oligodeoxynucleotides containing unmethylated CpG motifs (CpG ODN) prevent development of T-helper type 2 (Th2) immune response and reverse established allergic responses in mouse models. However, little work on immune responses in piglets has been conducted in vivo. In this report, the ability of a porcine-specific CpG ODN to act as an immunostimulant and enhance immune responses of piglets to swine Pasteurella multocida living vaccine (SPML vaccine) was determined. The titre of IgG and IgG1/IgG2 isotype to SPML vaccine in serum, the proliferation of lymphocytes, SPML-specific interferon-gamma (IFN-gamma) and IL-6, TNF-alpha, IL-4 production of PBMCs in vitro and IFN-gamma, IL-6, TNF-alpha, IL-4, IL-10 in piglets serum were examined to identify the immune responses of the piglets. Immune responses of the piglets vaccinated with SPML and CpG ODN were significantly stronger than responses of piglets vaccinated with SPML alone. All these data summarized that immunostimulatory CpG ODN could modulate the immune response towards a Th1-like response when co-administered to piglets during SPML vaccination, which suggested that the therapeutic uses envisioned for these ODNs (as vaccine adjuvants and immunoprotective agents) may be applicable to husbandry animals.

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