您好,欢迎访问广东省农业科学院 机构知识库!

Vaccination with porcine reproductive and respiratory syndrome killed virus vaccine and immunostimulatory oligodeoxynucleotides induces specitic immunity in piglets

文献类型: 外文期刊

作者: Zhang Linghua 1 ; Tian Xingshan 2 ; Zhou Fengzhen 2 ;

作者机构: 1.S China Agr Univ, Coll Life Sci, Guangzhou 510642, Guangdong, Peoples R China

2.S China Agr Univ, Coll Life Sci, Guangzhou 510642, Guangdong, Peoples R China; Guangdong Acad Agr Sci, Guangzhou 510642, Guangdong, Peoples R China

关键词: the piglets;porcine reproductive and respiratory syndrome killed virus vaccine;CpG ODN;immune response

期刊名称:VACCINE ( 影响因子:3.641; 五年影响因子:3.816 )

ISSN: 0264-410X

年卷期: 2007 年 25 卷 10 期

页码:

收录情况: SCI

摘要: A large number of studies demonstrated the immunostimulatory effects of CpG oligonucleotides (ODN), particularly in mice. In present study, the objective was to investigate the immunoadjuvant effects of CpG ODN to porcine reproductive and respiratory syndrome (PRRS) killed virus vaccine (PRRSV) and its protective effects against PRRS virus in piglets. The PRRSV-specific antibodies titres and serum IgG1/IgG2 titres, the proliferation of lymphocytes, PRRSV-specific IFN-gamma, the expression of major histocompatibility complex class II (MHCII) of peripheral blood mononuclear cells (PBMCs) and post-challenge clinical protection were examined to identify the immune responses of the piglets. The results were found that the above-mentioned immune responses of the piglets inoculated with CpG ODN plus PRRSV were significantly stronger than those indued by PRRSV or PBS control groups. All these data suggested that CpG ODN could be employed as effective immunoadjuvant to raise the Immoral and cellular responses of the piglets to PRRSV. (c) 2006 Elsevier Ltd. All rights reserved.

  • 相关文献

[1]The efficacy of CpG oligodinucleotides, in combination with conventional adjuvants, as immunological adjuvants to swine streptococcic septicemia vaccine in piglets in vivo. Zhang Linghua,Tian Xingshan,Zhou Fengzhen. 2006

[2]CpG oligodinucleotides induce strong humoral and cellular responses to swine streptococcic septicemia vaccine in piglets in vivo. Zhang, LH,Guo, Y,Tian, XS,Zhou, FZ. 2006

[3]Intranasal administration of CpG oligonucleotides induces mucosal and systemic Type 1 immune responses and adjuvant activity to porcine reproductive and respiratory syndrome killed virus vaccine in piglets in vivo. Zhang, Linghua,Tian, Xingshan,Zhou, Fengzhen. 2007

[4]CpG oligodeoxynucleotide protect neonatal piglets from challenge with the enterotoxigenic E. coli. Cai, Haiming,Shi, Juqing,Chu, Pingping,Huang, Chaoyuan,Yang, Jun,Zhang, Linghua,Kuang, Zheshi,Zhao, Xiangjie,Huang, Kuiying,Ming, Feiping,Xia, Fenggeng.

[5]Effects of CpG ODN on CD4(+) and CD8(+) T subpopulations in the immune response to porcine reproductive and respiratory syndrome killed virus vaccine. Zhang, LH,Tian, XS,Guo, Y,Zhou, FZ. 2006

[6]In vivo immunostimulatory effects of CpG ODN in newborn piglets. Zhang Linghua,Tian Xingshan,Zhou Fengzhen. 2007

[7]In vivo effects of oligodeoxynucleotides containing synthetic immunostimulatory motifs in the immune response to swine streptococcic septicemia vaccine in weaned piglets. Zhang Linghua,Tian Xingshan,Zhou Fengzhen. 2007

[8]In vivo effects of oligodeoxynucleotides containing synthetic immunostimulatory motifs in weaned piglets. Zhang, Linghua,Tian, Xingshan,Zhou, Fengzhen. 2006

[9]Vaccination with Newcastle disease vaccine and CpG oligodeoxynucleotides induces specific immunity and protection against Newcastle disease virus in SPF chicken. Zhang Linghua,Tian Xingshan,Zhou Fengzhen. 2007

[10]Co-administration of porcine-specific CpG oligodeoxynucleotide enhances the immune responses to pseudorabies attenuated virus vaccine in newborn piglets in vivo. Zhang, LH,Guo, Y,Tian, XS,Zhou, FZ.

[11]Enhancement of mucosal immune responses by intranasal co-delivery of Newcastle disease vaccine plus CpG oligonucleotide in SPF chickens in vivo. Zhang, Linghua,Zhang, Meirong,Li, Jiaoqing,Cao, Ting,Tian, Xingshan,Zhou, Fengzhen. 2008

[12]A genome-wide association study identifies major loci affecting the immune response against infectious bronchitis virus in chicken. Luo, Chenglong,Qu, Hao,Ma, Jie,Wang, Jie,Shu, Dingming,Hu, Xiaoxiang,Li, Ning,Luo, Chenglong,Qu, Hao,Ma, Jie,Wang, Jie,Shu, Dingming. 2014

[13]Effect of transgenic expression of porcine interleukin-6 gene and CpG sequences on immune responses of newborn piglets inoculated with Pseudorabies attenuated vaccine. Zhang, LH,Tian, XS,Guo, Y,Zhou, FZ,Meng, MJ. 2006

[14]Equol Inhibits LPS-Induced Oxidative Stress and Enhances the Immune Response in Chicken HD11 Macrophages. Gou, Zhongyong,Jiang, Shouqun,Zheng, Chuntian,Tian, Zhimei,Lin, Xiajing. 2015

[15]Effects of dietary glycyl-glutamine on growth performance, small intestinal integrity, and immune responses of weaning piglets challenged with lipopolysaccharide. Jiang, Z. Y.,Lin, Y. C.,Ma, X. Y.,Zheng, C. T.,Zhou, G. L.,Chen, F.,Zou, S. T.,Sun, L. H..

[16]Effect of long-term administration of dietary beta-1,3-glucan on growth, physiological, and immune responses in Litopenaeus vannamei (Boone, 1931). Zhao, Hong-Xia,Wang, An-Li,Ye, Chao-Xia,Zhao, Hong-Xia,Cao, Jun-Ming,Huang, Yan-Hua,Lan, Han-Bing,Zhou, Ting-Ting,Li, Guo-Li,Du, Zhen-Yu.

[17]Effect of dietary beta-1,3-glucan on the immune response of Litopenaeus vannamei exposed to nitrite-N. Zhao, H-X,Cao, J-M,Huang, Y-H,Li, G-L,Lan, H-B,Zhao, H-X,Wang, A-L,Tian, J-X,Du, Z-Y.

作者其他论文 更多>>