Withdrawal Interval Estimation of Doxycycline in Yellow Catfish (Pelteobagrus fulvidraco) Using an LC-MS/MS Method Based upon QuEChERS Sampling Preparation
文献类型： 外文期刊
作者： Xu, Ning 1 ; Cheng, Bo 3 ; Li, Miao 4 ; Lin, Zhoumeng 4 ; Ai, Xiaohui 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Wuhan 430223, Peoples R China
2.Hu Bei Prov Engn & Technol Res Ctr Aquat Product, Wuhan 430223, Peoples R China
3.Chinese Acad Fishery Sci, Aquat Prod Qual & Standard Res Ctr, Beijing 100141, Peoples R China
4.Kansas State Univ, Inst Computat Comparat Med ICCM, Dept Anat & Physiol, Coll Vet Med, Manhattan, KS 66506 USA
关键词： doxycycline;
LC-MS/MS
; QuEChERs; withdrawal time; yellow catfish期刊名称：FOODS （ 影响因子：4.35； 五年影响因子：4.957 ）
ISSN：
年卷期： 2021 年 10 卷 11 期
页码：
收录情况： SCI
摘要： Limited information on residue depletion of doxycycline (DC) is available in yellow catfish (Pelteobagrus fulvidraco) using the determination of LC-MS/MS based upon a rapid and simple method of sample preparation. This study collected plasma and tissue samples of yellow catfish at pre-determined time points following 3-day consecutive oral administration of DC at 20 mg/kg. The samples were prepared using a QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe) approach. The limit of detection and the limit of quantitation were 2.5 and 5 mu g/kg or mu g/L, respectively, for DC in plasma and tissues (e.g., muscle + skin, liver, kidney, and gill). The recoveries of DC ranged from 67.2% to 86.2%. The decision limit (CC alpha) and the detection capability (CC beta) were from 106.2 to 127.8 mu g/kg or mu g/L. The withdrawal times of DC in muscle + skin were estimated to be 22 d based on the guidelines in China and Europe and 27 d based on Japan's standard. Overall, this study not only provides an efficient method to rapidly determine the DC concentrations in fish-derived tissues but also provides important information on the safety assessment of DC in aquatic animal-derived food products.
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