PPAR Signaling Maintains Metabolic Homeostasis under Hypothermia in Freshwater Drum (Aplodinotus grunniens)
文献类型： 外文期刊
作者： Wu, Ningyuan 1 ; Wen, Haibo 1 ; Xu, Pao 1 ; Chen, Jianxiang 2 ; Xue, Miaomiao 2 ; Li, Jianlin 1 ; Wang, Meiyao 1 ; Song, Changyou 1 ; Li, Hongxia 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, 9 Shanshui East Rd, Wuxi 214081, Peoples R China
2.Nanjing Agr Univ, Wuxi Fisheries Coll, Wuxi 214081, Peoples R China
关键词： Aplodinotus grunniens; hypothermia; lipid metabolism; amino acid metabolism; PPAR signaling
期刊名称：METABOLITES （ 影响因子：4.1； 五年影响因子：4.5 ）
ISSN：
年卷期： 2023 年 13 卷 1 期
页码：
收录情况： SCI
摘要： Aplodinotus grunniens, known as freshwater drum, is a kind of eurythermal freshwater fish that is widely distributed in North America. In 2019, our research group reached a milestone on its artificial breeding and cultivation and have investigated its physiological adaption to the environment, providing a breakthrough and prospects for aquaculture. However, its adaptability and metabolic homeostasis to hypothermia is not fully understood. In this experiment, cold stress was conducted at 18 degrees C (LT18) and 10 degrees C (LT10) with 25 degrees C as control (Con) for 8 days to explore the effects of short-term hypothermia on the physiology and metabolism of freshwater drum. From the results, the level of free essential amino acids in LT18 and LT10 decreased significantly after 2 days cold stress compared with Con. Furthermore, plasma total triglyceride (TG) content and lipase (LPS) activity were decreased at LT10 for 2d. With RNA-seq in the liver, metabolic-related signaling, especially amino acid synthesis and lipid metabolism, was inhibited by hypothermia. Specifically, the PPAR signaling pathway is correlated with the inhibition of lipid and amino acid metabolism induced by hypothermia. These data confirmed that PPAR signaling maintains lipid and amino acid metabolic homeostasis during cold stress. These results give a theoretical foundation for hypothermia resistance in the area of metabolic homeostasis for freshwater drum.
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