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Absorption, transportation, residual distribution of chiral 14C-dufulin in garlics and metabolism of its racemate

文献类型： 外文期刊

作者： Zheng, Ruonan 1 ; Wang, Binjie 1 ; Wang, Jiye 1 ; Cheng, Xi 3 ; Ye, Qingfu 2 ;

作者机构： 1.Zhejiang Police Coll, Dept Criminal Sci & Technol, Zhejiang Key Lab Drug Prevent & Control Technol, Hangzhou 310051, Zhejiang, Peoples R China

2.Zhejiang Univ, Inst Nucl Agr Sci, Key Lab Nucl Agr Sci Minist Agr PRC & Zhejiang Pro, Hangzhou 310058, Peoples R China

3.Zhejiang Acad Agr Sci, Inst Agroprod Safety & Nutr, State Key Lab Managing Biot & Chem Threats Qual &, Key Lab Pesticide Residue Detect Minist Agr & Rura, Hangzhou 310021, Peoples R China

关键词： C-14-dufulin; Stereoselective; Translocation; Metabolites; Residue

期刊名称：FOOD CHEMISTRY （ 影响因子：9.8； 五年影响因子：9.7 ）

ISSN： 0308-8146

年卷期： 2025 年 463 卷

页码：

收录情况： SCI

摘要： Dufulin is a novel chiral plant antiviral agent. In this study, we investigated the uptake, translocation and accumulation of C-14-dufulin stereoisomers in different tissues of garlic via leaf introduction and root uptake. The behavior of dufulin enantiomers in plants is not stereoselective, and dufulin is more likely to be absorbed by leaves than by roots. The metabolites of C-14-dufulin with high specific activity in garlic were qualitatively and quantitatively analyzed by HPLC-QTOF-MS, and the metabolic pathway involved was elucidated. In the leaf and bulb, dufulin underwent phase I and phase II metabolism and produced four metabolites. The ratios and concentrations of these four metabolites in the bulb, but not in the leaf, met the residue criterion. Overall, our results provide relatively accurate predictions for the risk assessment of dufulin, which will help guide its rational use and ensure its ecological safety and human health.

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