Phylogenetic and Phylogeographic Analysis of the Highly Pathogenic H5N6 Avian Influenza Virus in China
文献类型： 外文期刊
作者： Liu, Hanlin 1 ; Wu, Changrong 1 ; Pang, Zifeng 1 ; Zhao, Rui 1 ; Liao, Ming 4 ; Sun, Hailiang 1 ;
作者机构： 1.South China Agr Univ, Coll Vet Med, Guangzhou 510642, Peoples R China
2.South China Agr Univ, Key Lab Zoonosis Control & Prevent Guangdong Prov, Guangzhou 510642, Peoples R China
3.South China Agr Univ, Natl & Reg Joint Engn Lab Medicament Zoonosis Pre, Guangzhou 510642, Peoples R China
4.Guangdong Acad Agr Sci, Inst Anim Hlth, Guangzhou 510640, Peoples R China
5.Minist Agr & Rural Affairs, Key Lab Prevent & Control Avian Influenza & Other, Guangzhou 510640, Peoples R China
关键词： 2; 3; 4; 4b reassortant; evolution; phylogeographic analysis
期刊名称：VIRUSES-BASEL （ 影响因子：5.818； 五年影响因子：5.811 ）
ISSN：
年卷期： 2022 年 14 卷 8 期
页码：
收录情况： SCI
摘要： The clade 2.3.4.4b H5N8 avian influenza viruses (AIVs) have caused the loss of more than 33 million domestic poultry worldwide since January 2020. Novel H5N6 reassortants with hemagglutinin (HA) from clade 2.3.4.4b H5N8 AIVs are responsible for multiple human infections in China. Therefore, we conducted an epidemiological survey on waterfowl farms in Sichuan and Guangxi provinces and performed a comprehensive spatiotemporal analysis of H5N6 AIVs in China. At the nucleotide level, the H5N6 AIVs isolated in the present study exhibited high homology with the H5N6 AIVs that caused human infections. Demographic history indicates that clade 2.3.4.4b seemingly replaced clade 2.3.4.4h to become China's predominant H5N6 AIV clade. Based on genomic diversity, we classified clade 2.3.4.4b H5N6 AIV into ten genotypes (2.3.4.4bG1-G10), of which the 2.3.4.4bG5 and G10 AIVs can cause human infections. Phylogeographic results suggest that Hong Kong and Jiangxi acted as important epicentres for clades 2.3.4.4b and 2.3.4.4h, respectively. Taken together, our study provides critical insight into the evolution and spread of H5N6 AIVs in China, which indicates that the novel 2.3.4.4b reassortants pose challenges for public health and poultry.
- 相关文献
作者其他论文 更多>>
-
Salmonella Typhimurium persistently infects host via its effector SseJ-induced PHB2-mediated mitophagy
作者：Sun, Dage;Li, Jiayi;Dai, Changzhi;Chen, Kaifeng;Wang, Yu;Pan, Peng;Zhu, Ting;Xu, Chenggang;Liao, Ming;Zhang, Jianmin;Gou, Hongchao;Shen, Haiyan;Zhang, Yu;Shan, Tongling;Liao, Ming
关键词：Mitophagy; PHB2; PINK1; PRKN;
Salmonella Typhimurium; SseJ -
Genome-scale evolution and phylodynamics of swine influenza A viruses in China: a genomic epidemiology study
作者：Sun, Hailiang;Liu, Hanlin;Qu, Xiaoyun;Pang, Zifeng;Xu, Fengxiang;Wu, Changrong;Jiang, Yinglin;Sun, Hailiang;Liu, Hanlin;Qu, Xiaoyun;Pang, Zifeng;Xu, Fengxiang;Wu, Changrong;Jiang, Yinglin;Zhang, Jianfeng;Shi, Mang;Zhang, Jianfeng;Liao, Ming;Shi, Mang;Liu, Quan;Liu, Quan;Liu, Quan
关键词：
-
Identification and characterization of a broadly neutralizing and protective nanobody against the HA1 domain of H5 avian influenza virus hemagglutinin
作者：Xu, Siqi;Liu, Yutong;Zhou, Mengruo;Wang, Ke;Xie, Qianmei;Zhang, Qi;Zhang, Qinying;Li, Qianyu;Pan, Zhichao;Feng, Saixiang;Liao, Ming;Luo, Chenying;Liao, Ming;Liao, Ming
关键词：influenza virus; yeast two-hybrid; nanobody; broadly neutralizing; surface plasmon resonance; inhibition mechanism; prophylactic; therapeutic; epitope mapping
-
Newly identified c-di-GMP pathway putative EAL domain gene STM0343 regulates stress resistance and virulence in Salmonella enterica serovar Typhimurium
作者：Chen, Kaifeng;Li, Lili;Wang, Nanwei;Zhou, Zhouping;Pan, Peng;Xu, Chenggang;Sun, Dage;Li, Jiayi;Dai, Changzhi;Liao, Ming;Zhang, Jianmin;Liao, Ming;Kuang, Dai
关键词：
S. Typhimurium; c-di-GMP; EAL; stress resistance; virulence -
A Smart Single-Loop-Mediated Isothermal Amplification Facilitates Flexible SNP Probe Design for On-Site Rapid Differentiation of SARS-CoV-2 Omicron Variants
作者：Lin, Qijie;Qu, Xiaoyun;Deng, Yuhui;Cai, Qianyi;Liang, Yucen;Xu, Xiaozhen;Liu, Ruidong;Zhang, Jianmin;Liao, Ming;Gou, Hongchao;Du, Shouwen;Jia, Kaiyuan;Lin, Jianhan;Li, Dan;Yan, Bailing;Li, Yanbin;Li, Letian;Jiang, Yuhang;Deng, Lingcong;Li, Chang;Liao, Ming
关键词：nucleic acid amplification; SARS-CoV-2 variants of concern; SNP detection; ssLAMP
-
Evaluation and Characterization of Acute respiratory distress syndrome in tree shrews through TMT proteomic method
作者：Xiong, Junlong;Xing, Jinchao;Zhang, Liji;Liao, Ming;Zhang, Liji;Huang, Weijian;Wang, Ning;Lin, Xiaoyan;He, Shuhua;He, Jun;Liao, Ming
关键词：
-
Isolation, Characterization, and Comparative Analysis of Two Subtypes of Goose Astrovirus in Guangdong Province, China
作者：Liu, Chenggang;Li, Linlin;Dong, Jiawen;Xiang, Yong;Zhang, Junqin;Zhai, Qi;Huang, Yunzhen;Liao, Ming;Sun, Minhua;Liu, Chenggang;Jin, Jin;Sun, Binyi;Liao, Ming
关键词：goose astrovirus; gout; phylogenetic analysis; tissue tropism; protein structure
