Nontarget Screening and Toxicity Evaluation of Diol Esters of Okadaic Acid and Dinophysistoxins Reveal Intraspecies Difference of Prorocentrum lima
文献类型： 外文期刊
作者： Wu, Haiyan 1 ; Chen, Jiaqi 1 ; Peng, Jixing 1 ; Zhong, Yun 1 ; Zheng, Guanchao 1 ; Guo, Mengmeng 1 ; Tan, Zhijun 1 ; Zhai 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Key Lab Testing & Evaluat Aquat Prod Safety & Qua, Minist Agr & Rural Affairs, Yellow Sea Fisheries Res Inst, Qingdao 266071, Peoples R China
2.Pilot Natl Lab Marine Sci & Technol Qingdao, Qingdao 266071, Peoples R China
3.Jinan Univ, Coll Life Sci & Technol, Guangzhou 510632, Peoples R China
期刊名称：ENVIRONMENTAL SCIENCE & TECHNOLOGY （ 影响因子：9.028； 五年影响因子：9.922 ）
ISSN： 0013-936X
年卷期： 2020 年 54 卷 19 期
页码：
收录情况： SCI
摘要： High-resolution mass spectrometry (HRMS) analysis with the assistance of molecular networking was used to investigate intracellular toxin profiles of five Prorocentrum lima (P. lima) strains sampled from the north Yellow Sea and South China Sea. Mice were used as a model species for testing the acute toxicity of intracellular okadaic acid (OA) and dinophysistoxins (DTXs) in free and esterified states. Results showed that OA and DTX1 esterified derivatives were detected in all P. lima samples, accounting for 55%-96% of total toxins in five strains. A total of 24 esters and 1 stereoisomer of DTX1 (35S DTX1) were identified based on molecular networking and MS data analysis, 15 esters of which have been reported first. All P. lima strains displayed specific toxin profiles, and preliminary analysis suggested that toxin profiles of the five P. lima strains might be region-related. Moreover, acute toxicity in mice suggested higher toxicity of esters compared with free toxins, which highlights the importance and urgency of attention to esterified toxins in P. lima.
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