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Marek's Disease Virus (Gallid alphaherpesvirus 2)-Encoded miR-M2-5p Simultaneously Promotes Cell Proliferation and Suppresses Apoptosis Through RBM24 and MYOD1-Mediated Signaling Pathways

文献类型： 外文期刊

作者： Zhu, Zhi-Jian 1 ; Teng, Man 2 ; Li, Hui-Zhen 2 ; Zheng, Lu-Ping 2 ; Liu, Jin-Ling 2 ; Chai, Shu-Jun 2 ; Yao, Yong-Xiu; 1 ;

作者机构： 1.Sichuan Agr Univ, Coll Vet Med, Res Ctr Avian Dis, Chengdu, Peoples R China

2.Henan Acad Agr Sci, Minist Agr, Key Lab Anim Immunol, Zhengzhou, Peoples R China

3.Henan Acad Agr Sci, Henan Prov Key Lab Anim Immunol, Zhengzhou, Peoples R China

4.Henan Acad Agr Sci, UK China Ctr Excellence Res Avian Dis, Zhengzhou, Peoples R China

5.Henan Agr Univ, Coll Anim Sci & Vet Med, Zhengzhou, Peoples R China

6.Pirbright Inst, Guildford, Surrey, England

7.UK China Ctr Excellence Res Avian Dis, Guildford, Surrey, England

8.Yangzhou Univ, Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou, Jiangsu, Peoples R China

9.Henan Univ Sci & Technol, Coll Anim Sci & Technol, Key Lab Anim Dis & Publ Safety, Luoyang, Peoples R China

关键词： herpesvirus; Gallid alphaherpesvirus 2; oncogenesis; miRNA; miR-M2-5p; RNA-binding protein 24; myogenic differentiation 1; Marek’ s disease

期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：5.64； 五年影响因子：6.32 ）

ISSN： 1664-302X

年卷期： 2020 年 11 卷

页码：

收录情况： SCI

摘要： MicroRNAs (miRNAs) have been demonstrated for their involvement in virus biology and pathogenesis, including functioning as key determinants of virally-induced cancers. As an important oncogenic alpha-herpesvirus affecting poultry health, Marek's disease virus serotype 1 [Gallid alphaherpesvirus 2 (GaHV-2)] induces rapid-onset T-cell lymphomatous disease commonly referred to as Marek's disease (MD), an excellent biological model for the study of virally-induced cancer in the natural hosts. Previously, we have demonstrated that GaHV-2-encoded miRNAs (especially those within the Meq-cluster) have the potential to act as critical regulators of multiple processes such as virus replication, latency, pathogenesis, and/or oncogenesis. In addition to miR-M4-5p (miR-155 homolog) and miR-M3-5p, we have recently found that miR-M2-5p possibly participate in inducing MD lymphomagenesis. Here, we report the identification of two tumor suppressors, the RNA-binding protein 24 (RBM24) and myogenic differentiation 1 (MYOD1), being two biological targets for miR-M2-5p. Our experiments revealed that as a critical miRNA, miR-M2-5p promotes cell proliferation via regulating the RBM24-mediated p63 overexpression and MYOD1-mediated IGF2 signaling and suppresses apoptosis by targeting the MYOD1-mediated Caspase-3 signaling pathway. Our data present a new strategy of a single viral miRNA exerting dual role to potentially participate in the virally-induced T-cell lymphomagenesis by simultaneously promoting the cell proliferation and suppressing apoptosis.

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