Safety, Immunogenicity, and Effectiveness of Defective Viral Particles Arising in Mast Cells Against Influenza in Mice
文献类型： 外文期刊
作者： Huo, Caiyun 1 ; Tian, Jijing 1 ; Cheng, Jinlong 1 ; Xiao, Jin 3 ; Chen, Mingyong 1 ; Zou, Shumei 4 ; Tian, Haiyan 1 ; Wan 1 ;
作者机构： 1.China Agr Univ, Coll Vet Med, Key Lab Anim Epidemiol Minist Agr, Beijing, Peoples R China
2.Beijing Acad Agr & Forestry Sci, Inst Anim Husb & Vet Med, Beijing Key Lab Prevent & Control Infect Dis Live, Beijing, Peoples R China
3.Zhongmu Inst China Anim Husb Ind Co Ltd, Minist Agr, Key Lab Vet Bioprod & Chem Med, Beijing, Peoples R China
4.Natl Inst Viral Dis Control & Prevent, Collaborat Innovat Ctr Diag & Treatment Infect Di, Chinese Ctr Dis Control & Prevent, Key Lab Med Virol,Natl Hlth & Family Planning Com, Beijing, Peoples R China
关键词： mast cells; defective viral particles; immunogenicity; protective immune reaction
期刊名称：FRONTIERS IN IMMUNOLOGY （ 影响因子：7.561； 五年影响因子：7.624 ）
ISSN： 1664-3224
年卷期： 2020 年 11 卷
页码：
收录情况： SCI
摘要： Mast cells play pivotal roles in the pathogenesis of influenza A virus (IAV) infections. Defective viral particles (DPs) often arise during IAV replication, which can interfere with the replication of infectious viruses and stimulate the antiviral response of host cells. Therefore, DPs are expected to have immune-protective functions in clinic. However, the potent immunogenicity and effectiveness of DPs arising in mast cells during IAV replication have not been reported. In the present study, we showed that DPs generated in the human mastocytoma cell line HMC-1 following H1N1 infection were safe to mice after vaccination. Compared with lung adenocarcinoma cells, A549, DPs generated in infected mast cells had much better immunostimulatory activity, enhancing both humoral and cellular immunity of hosts. Notably, they could significantly increase the expression of immune-associated cytokines, especially the IFN-gamma. Due to the robust immunogenicity, thus DPs generated in infected mast cells could stimulate the robust protective immune reaction effectively to fight against lethal IAV re-challenge after vaccination, which result in the high survival, decreased lung injury as well as inhibition of viral replication and inflammatory response in lungs. This study is the first to illustrate and explore the safety, immunogenicity, and effectiveness of DPs arising in mast cells against influenza as favorable potential vaccination. The results provide insight into the advances of new prophylactic strategies to fight influenza by focusing on DPs generated in mast cells.
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