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Lipopeptide Epimers and a Phthalide Glycerol Ether with AChE Inhibitory Activities from the Marine-Derived Fungus Cochliobolus Lunatus SCSIO41401

文献类型： 外文期刊

作者： Dai, Yu 1 ; Li, Kunlong 1 ; She, Jianglian 1 ; Zeng, Yanbo 3 ; Wang, Hao 3 ; Liao, Shengrong 1 ; Lin, Xiuping 1 ; Yang, B 1 ;

作者机构： 1.Chinese Acad Sci, South China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med, CAS Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Peoples R China

2.Southern Marine Sci & Engn Guangdong Lab Guangzho, Guangzhou 511458, Peoples R China

3.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Res & Dev Nat Prod Li Folk Med, Haikou 571101, Hainan, Peoples R China

4.Southern Med Univ, Sch Tradit Chinese Med, Guangzhou 510515, Peoples R China

5.Shenyang Pharmaceut Univ, Wuya Coll Innovat, Shenyang 110016, Peoples R China

关键词： lipopeptides; phthalide; Cochliobolus lunatus; absolute configurations; AChE inhibitory

期刊名称：MARINE DRUGS （ 影响因子：5.118； 五年影响因子：5.951 ）

ISSN：

年卷期： 2020 年 18 卷 11 期

页码：

收录情况： SCI

摘要： A pair of novel lipopeptide epimers, sinulariapeptides A (1) and B (2), and a new phthalide glycerol ether (3) were isolated from the marine algal-associated fungus Cochliobolus lunatus SCSIO41401, together with three known chromanone derivates (4-6). The structures of the new compounds, including the absolute configurations, were determined by comprehensive spectroscopic methods, experimental and calculated electronic circular dichroism (ECD), and Mo-2 (OAc)(4)-induced ECD methods. The new compounds 1-3 showed moderate inhibitory activity against acetylcholinesterase (AChE), with IC50 values of 1.3-2.5 mu M, and an in silico molecular docking study was also performed.

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