Lipopeptide Epimers and a Phthalide Glycerol Ether with AChE Inhibitory Activities from the Marine-Derived Fungus Cochliobolus Lunatus SCSIO41401
文献类型： 外文期刊
作者： Dai, Yu 1 ; Li, Kunlong 1 ; She, Jianglian 1 ; Zeng, Yanbo 3 ; Wang, Hao 3 ; Liao, Shengrong 1 ; Lin, Xiuping 1 ; Yang, B 1 ;
作者机构： 1.Chinese Acad Sci, South China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med, CAS Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Peoples R China
2.Southern Marine Sci & Engn Guangdong Lab Guangzho, Guangzhou 511458, Peoples R China
3.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Res & Dev Nat Prod Li Folk Med, Haikou 571101, Hainan, Peoples R China
4.Southern Med Univ, Sch Tradit Chinese Med, Guangzhou 510515, Peoples R China
5.Shenyang Pharmaceut Univ, Wuya Coll Innovat, Shenyang 110016, Peoples R China
关键词： lipopeptides; phthalide; Cochliobolus lunatus; absolute configurations; AChE inhibitory
期刊名称：MARINE DRUGS （ 影响因子：5.118； 五年影响因子：5.951 ）
ISSN：
年卷期： 2020 年 18 卷 11 期
页码：
收录情况： SCI
摘要： A pair of novel lipopeptide epimers, sinulariapeptides A (1) and B (2), and a new phthalide glycerol ether (3) were isolated from the marine algal-associated fungus Cochliobolus lunatus SCSIO41401, together with three known chromanone derivates (4-6). The structures of the new compounds, including the absolute configurations, were determined by comprehensive spectroscopic methods, experimental and calculated electronic circular dichroism (ECD), and Mo-2 (OAc)(4)-induced ECD methods. The new compounds 1-3 showed moderate inhibitory activity against acetylcholinesterase (AChE), with IC50 values of 1.3-2.5 mu M, and an in silico molecular docking study was also performed.
- 相关文献
作者其他论文 更多>>
-
Syntaxin 17 Translocation Mediated Mitophagy Switching Drives Hyperglycemia-Induced Vascular Injury
作者：Luo, Anqi;Liu, Xiaoquan;Liu, Haochen;Wang, Rui;Zheng, Yunsi;Gong, Jingwen;Wang, Shuting;Yun, Chuan;Chen, Zongcun;Jiang, Yanan;Dai, Haofu
关键词：(diabetes; Fis1; mitophagy; Syntaxin 17); vascular endothelial injury
-
Identification of targets and comparative study of administration methods for the lipid-lowering effects of fucoidan from Saccharina japonica
作者：Chen, Pengwei;Wang, Hao;Chen, Huiqin;Dai, Haofu;Hao, Li;Li, Quancai;Zhang, Miao;Jiang, Hongfei;Zhang, Renshuai;Jia, Ang
关键词：Fucoidan; Lipid-lowering activity; Dietary supplementation; Intestinal target; Gut microbiota
-
Comprehensive analysis of morphology, transcriptomics, and metabolomics of banana (Musa spp.) molecular mechanisms related to plant height
作者：Wei, Junya;Cheng, Shimin;Huang, Lina;Wei, Shouxing;Liu, Guoyin;Sun, Mingzhen;Wang, Hao;Liu, Debing;Yang, Ping
关键词：banana; metabolomics; transcriptomics; hormones; height
-
2-(2-Phenylethyl)chromone-Sesquiterpene Hybrids from Agarwood of Aquilaria sinensis: Characterization and Biological Activity Evaluation
作者：Xu, Guan-Hua;Liu, Shou-Bai;Xu, Guan-Hua;Wang, Ya-Li;Wang, Hao;Chen, Hui-Qin;Dong, Wen-Hua;Huang, Sheng-Zhuo;Cai, Cai-Hong;Yuan, Jing-Zhe;Mei, Wen-Li;Dai, Hao-Fu
关键词：Hainan agarwood; 2-(2-phenylethyl)chromone-sesquiterpene hybrids; structure elucidation; anti-inflammatory activity; neuroprotective activity; cytotoxic activity
-
Three new dimeric 2-(2-phenethyl)chromones from the agarwood of Aquilaria malaccensis
作者：Yan, Xian-Yun;Liang, Lin-Fu;Yan, Xian-Yun;Li, Wei;Wang, Hao;Dong, Wen-Hua;Zeng, Jun;Wu, Fei;Mei, Wen-Li;Dai, Hao-Fu;Yan, Xian-Yun;Li, Wei;Wang, Hao;Dong, Wen-Hua;Zeng, Jun;Wu, Fei;Mei, Wen-Li;Dai, Hao-Fu
关键词：Agarwood; Aquilaria malaccensis; 2-(2-phenethyl)chromone dimers; Anti-inflammatory activity
-
Comprehensive investigation of the C2H2-type zinc finger protein transcription factor family in Aquilaria sinensis reveals the involvement of AsZFP9 in sesquiterpene biosynthesis
作者：Li, Yuji;Guo, Dong;Wang, Hao;Wang, Ying;Peng, Shiqing;Dai, Haofu;Mei, Wenli;Zhu, Jiahong;Guo, Dong;Dai, Haofu;Zhu, Jiahong;Li, Yuji;Wang, Hao;Peng, Shiqing;Dai, Haofu;Mei, Wenli
关键词：Aquilaria sinensis; Zinc finger protein; Agarwood; Sesquiterpene biosynthesis
-
Nauclofficines A and B, two novel monoterpenoid indole alkaloids from the Li folk herb Nauclea officinalis with anti-allergic inflammatory effects on RBL-2H3 cells
作者：Li, Yan-li;Wang, Ting;Wang, Hao;Wang, Qi;Cai, Cai-Hong;Mei, Wen-Li;Dai, Hao-Fu;Huang, Sheng-Zhuo;Dai, Hao-Fu;Huang, Sheng-Zhuo;Li, Yan-li;Xu, Feng-Qing;Wang, Ting;Zhu, Guo-Peng
关键词：Nauclea officinalis; Monoterpenoid indole alkaloid; Li folk medicine; Anti-inflammatory activity; Nauclofficine
