文献类型： 外文期刊

作者： Wang, Pan ¹ ; Xie, Zhi-Shen ¹ ; Song, Jun-Ying ¹ ; Zeng, Hua-Hui ¹ ; Dai, Li-Ping ³ ; E, Heng-Chao ⁴ ; Ye, Zhi-Peng ² ; G ¹ ;

作者机构： 1.Henan Univ Chinese Med, Acad Chinese Med Sci, Zhengzhou 450046, Peoples R China

2.Zhongjing Wanxi Pharmaceut Co Ltd, Zhengzhou 450003, Peoples R China

3.Henan Univ Chinese Med, Coll Pharm, Zhengzhou 450046, Peoples R China

4.Shanghai Acad Agr Sci, Inst Agrifood Stand & Testing Technol, Shanghai 201403, Peoples R China

关键词： Atractylodes macrocephala; Sesquiterpenoid lactone; Bisesquiterpenoid; Atractylenolide; CREB agonist

期刊名称：FITOTERAPIA （ 影响因子：2.882； 五年影响因子：3.202 ）

ISSN： 0367-326X

年卷期： 2020 年 147 卷

页码：

收录情况： SCI

摘要： One new bisesquiterpenoid, biepiasreorlid II (1), three new sesquiterpene lactones 8 alpha-methoxy-epiasterolid (4), 3 beta-acetoxyl-8-epiasterolid (5), and 3 beta-acetoxyl-atractylenolide I (6), along with five known analogues (2-3 and 7-9), were obtained from rhizome of Atractylodes macrocephala Koidz. All structures were assigned on the basis of detailed spectroscopic analyses. The absolute configuration of 1 was established by the analysis of single-crystal X-ray diffraction with Ga K alpha radiation, and 4-6 were elucidated by TDDFT-ECD calculations. The CREB agonistic activity was investigated in HEK293T cells using dual luciferase reporter assay. Compounds 1, 2, 5, and 7-9 exhibited strong to agonistic activities on CREB.