文献类型： 外文期刊

作者： Wang, Pan ¹ ; Zhao, Yi-nan ³ ; Xu, Rui-zhu ³ ; Zhang, Xiao-wei ¹ ; Sun, Yi-ran ¹ ; Feng, Qing-mei ¹ ; Li, Zhong-hua ¹ ; Xu, Jiang-yan ¹ ; Xie, Zhi-shen ¹ ; Zhang, Zhen-qiang ¹ ; Heng-chao, E. ⁴ ;

作者机构： 1.Henan Univ Chinese Med, Acad Chinese Med Sci, Zhengzhou, Peoples R China

2.Zhongjing Wanxi Pharmaceut Co Ltd, Henan Prov Technol Innovat Ctr Solid Preparat Trad, Nanyang, Peoples R China

3.Henan Univ Chinese Med, Coll Pharm, Zhengzhou, Peoples R China

4.Shanghai Acad Agr Sci, Inst Agrifood Stand & Testing Technol, Shanghai, Peoples R China

关键词： sesquiterpene lactones; atractylenolactam; Atractylodes macrocephala; molecular networking; antioxidant activity

期刊名称：FRONTIERS IN NUTRITION （ 影响因子：6.59； 五年影响因子：6.873 ）

ISSN： 2296-861X

年卷期： 2022 年 9 卷

页码：

收录情况： SCI

摘要： Atractylodes macrocephala rhizome (called Bai-zhu in China) has a long history as a functional food and herbal medicine in East Asia, especially China. Sesquiterpenoids are one of the main active compounds of Atractylodes macrocephala rhizome. This study aimed to explore the unknown sesquiterpenoids of A. macrocephala rhizome using a molecular networking strategy. Two new nitrogen-containing sesquiterpenoids, atractylenolactam A (1) and atractylenolactam B (2), and 2 new sesquiterpene lactones, 8-methoxy-atractylenolide V (6) and 15-acetoxyl atractylenolide III (7), along with 12 known analogs (3-5 and 8-16) were discovered and isolated. All the structures were assigned based on detailed spectroscopic analyses. The absolute configurations of 1, 2, 6, and 7 were established by time-dependent density functional theory ECD (TDDFT-ECD) calculations. All these compounds had different degrees of concentration-dependent activating effects on nuclear-factor-E2-related factor-2 (Nrf2).