Transcriptomic evidence of luteinizing hormone-releasing hormone agonist (LHRH-A) regulation on lipid metabolism in grass carp (Ctenopharyngodon idella)
文献类型： 外文期刊
作者： Zhong, Huan 1 ; Hu, Jie 2 ; Zhou, Yi 3 ;
作者机构： 1.Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Peoples R China
2.Chinese Acad Fishery Sci, Pearl River Fisheries Res Inst, Minist Agr, Key Lab Trop & Subtrop Fisheries Resource Applica, Guangzhou 510385, Peoples R China
3.Hunan Normal Univ, State Key Lab Dev Biol Freshwater Fish, Changsha 410081, Peoples R China
4.Hunan Normal Univ, Life Sci Coll, Lushan Rd 36, Changsha 410081, Peoples R China
关键词： Grass carp; LHRH-A; Lipid metabolism; Gene ontology; KEGG pathway
期刊名称：GENOMICS （ 影响因子：5.736； 五年影响因子：4.939 ）
ISSN： 0888-7543
年卷期： 2021 年 113 卷 1 期
页码：
收录情况： SCI
摘要： In this study, RNA sequencing was used to identify the hepatic gene expression profile in grass carp associated with luteinizing hormone-releasing hormone agonist (LHRH-A) treatment. A total of 93,912,172 reads were generated by HiSeq 4000 sequencing platform. After filtering, 83,450,860 clean reads were mapped to the reference genome. By calculating the FPKM of genes, 1475 differentially expressed genes were identified. PPAR signaling pathway was enriched with upregulated genes in LHRH-A injection group showing the regulation of the lipid metabolism by LHRH-A. The expression of eight key genes in PPAR signaling pathway was confirmed by qPCR and the results suggested that ACSL4A, ACSL4B, ANGPTL4, LPL, RXRBA and SLC27A1B were significantly stimulated by LHRH-A injection. This investigation provides the evidence that LHRH-A could play a role in lipid metabolism.
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