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The Rice Aspartyl-tRNA Synthetase YLC3 Regulates Amino Acid Homeostasis and Chloroplast Development Under Low Temperature

文献类型： 外文期刊

作者： Liu, Hongjia 1 ; Gong, Xue 1 ; Deng, Hui 2 ; Tan, Jinjuan 1 ; Sun, Yanqing 3 ; Wang, Fang 1 ; Wu, Wenjuan 5 ; Zhou, Zhongjing 1 ; Xu, Rumeng 1 ; He, Haiyan 1 ; Lo, Clive 6 ;

作者机构： 1.Zhejiang Acad Agr Sci, Inst Virol & Biotechnol, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou, Peoples R China

2.Fujian Agr & Forestry Univ, Coll Life Sci, Fuzhou, Peoples R China

3.Zhejiang Univ, Inst Crop Sci, Hangzhou, Peoples R China

4.Zhejiang Univ, Inst Bioinformat, Hangzhou, Peoples R China

5.Shanghai Normal Univ, Coll Life Sci, Shanghai Key Lab Plant Mol Sci, Shanghai, Peoples R China

6.Univ Hong Kong, Sch Biol Sci, Hong Kong, Peoples R China

关键词： rice; aspartyl-tRNA synthetase; chloroplast; amino acid metabolism; eiF2a

期刊名称：FRONTIERS IN PLANT SCIENCE （ 影响因子：6.627； 五年影响因子：7.255 ）

ISSN： 1664-462X

年卷期： 2022 年 13 卷

页码：

收录情况： SCI

摘要： Aminoacyl tRNA synthetases primarily function to attach specific amino acids to the corresponding tRNAs during protein translation. However, their roles in regulating plant growth and development still remain elusive. Here we reported a rice thermo-sensitive mutant yellow leaf chlorosis3 (ylc3) with reduced chlorophyll content, altered thylakoid structure, and substantially elevated levels of free aspartate, asparagine and glutamine in leaves under low temperature condition. Map-based cloning identified that YLC3 encodes an aspartyl-tRNA synthetase which is localized in cytosol and mitochondria. In addition, quantitative proteomics analysis revealed that both nuclear and chloroplast-encoded thylakoid proteins were significantly down-regulated in the mutant. On the other hand, proteins involved in amino acid metabolism and the process of protein synthesis were up-regulated in ylc3, particularly for key enzymes that convert aspartate to asparagine. Moreover, uncharged tRNA-Asp accumulation and phosphorylation of the translation initiation factor eIF2 alpha was detected in the mutant, suggesting that YLC3 regulates the homeostasis of amino acid metabolism and chloroplast thylakoid development through modulation of processes during protein synthesis.

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