文献类型： 外文期刊
作者： Li, Linmiao 1 ; Wang, Xiaohu 2 ; Hua, Yan 3 ; Liu, Ping 1 ; Zhou, Jiabin 1 ; Chen, Jing 2 ; An, Fuyu 3 ; Hou, Fanghui 4 ; Hu 1 ;
作者机构： 1.Guangdong Acad Sci, Inst Zool, Guangdong Publ Lab Wild Anim Conservat & Utilizat, Guangdong Key Lab Anim Conservat & Resource Utili, Guangzhou, Peoples R China
2.Guangdong Acad Agr Sci, Inst Anim Hlth, Guangzhou, Peoples R China
3.Guangdong Acad Forestry, Guangdong Prov Key Lab Silviculture Protect & Uti, Guangzhou, Peoples R China
4.Guangdong Prov Wildlife Rescue Ctr, Guangzhou, Peoples R China
关键词： Betacoronavirus; epidemiology; Malayan pangolin; ACE2; phylogenetic analysis
期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：4.235； 五年影响因子：4.926 ）
ISSN： 1664-302X
年卷期： 2021 年 12 卷
页码：
收录情况： SCI
摘要： The coronavirus disease 2019 (COVID-19) outbreak has significantly affected international public health safety. It has been reported that the pathogen severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19, could originate from bats and utilize the Malayan pangolin (Manis javanica) as an intermediate host. To gain further insights into the coronaviruses carried by pangolins, we investigated the occurrence of Betacoronavirus (beta-CoV) infections in captive Malayan pangolins in the Guangdong province of China. We detected three beta-CoV-positive M. javanica individuals with a positive rate of 6.98% and also detected beta-CoV in two dead pangolins sampled in August 2019. The CoV carried by pangolins is a new beta-CoV, which is genetically related to SARS-CoV-2. Furthermore, the expression of angiotensin-converting enzyme 2 (ACE2) was detected in eight organs of pangolins, with the highest ACE2 mRNA levels in the kidney, suggesting that these organs could be at a risk of beta-CoV infection. These results enable us to better understand the status of beta-CoV carried by Malayan pangolins, while providing a theoretical basis for better pangolin protection and viral control.
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