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Iodine-catalyzed sulfuration of isoquinolin-1(2H)-ones applying ethyl sulfinates

文献类型: 外文期刊

作者: Mu, Yangxiu 1 ; Yang, Minghua 2 ; Li, Fengxia 1 ; Iqbal, Zafar 1 ; Jiang, Rui 1 ; Hou, Jing 1 ; Guo, Xin 3 ; Yang, Zhixia 1 ;

作者机构: 1.Ningxia Acad Agr & Forestry Sci, Agr Resource & Environm Inst, Yinchuan 750002, Ningxia, Peoples R China

2.Lishui Univ, Dept Chem, Lishui 323000, Peoples R China

3.North Minzu Univ, Dept Pharmaceut Engn, Sch Chem & Chem Engn, Yinchuan 750002, Ningxia, Peoples R China

期刊名称:NEW JOURNAL OF CHEMISTRY ( 影响因子:3.288; 五年影响因子:3.153 )

ISSN: 1144-0546

年卷期: 2021 年 45 卷 11 期

页码:

收录情况: SCI

摘要: An efficient sulfuration of isoquinolin-1(2H)-ones at the C-4 position is reported by employing ethyl sulfinates, and the corresponding products are obtained in moderate to excellent yields in the presence of iodine. This synthetic strategy provides a range of thioether-isoquinolin-1(2H)-ones while tolerating a number of functional groups on the isoquinoline nitrogen atom and benzene ring. In addition, pyridin-2(1H)-one is also reacted smoothly and afforded the corresponding thioether product in moderate yield. A plausible mechanism is suggested based on the preliminary mechanistic studies.

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