文献类型： 外文期刊
作者： Zhai, Lijuan 1 ; Sun, Jian 1 ; Zhou, Pengjuan 1 ; Ji, Jingwen 1 ; He, Lili 1 ; Tang, Dong 1 ; Ji, Jinbo 1 ; Yang, Haikang 1 ; Iqbal, Zafar 1 ; Yang, Zhixiang 1 ;
作者机构： 1.Ningxia Acad Agr & Forestry Sci, Ningxia Ctr Organ Synth & Engn Technol, 590 Huanghe East Rd, Yinchuan 750002, Ningxia, Peoples R China
关键词： kukoamine A; natural product; dihydrocaffeic acid; spermine
期刊名称：CHEMISTRY OF NATURAL COMPOUNDS （ 影响因子：0.8； 五年影响因子：0.8 ）
ISSN： 0009-3130
年卷期： 2024 年
页码：
收录情况： SCI
摘要： Kukoamine A has been known for decades as an anti-inflammatory and hypotensive principle of Chinese medicinal plant extract from Lycium root, bark, and fruit. The recent pharmacological significance of this alkaloid makes it a potential therapeutic target for the pharmaceutical industry. We accomplished the synthesis of kukoamine A in a 73% yield over four steps starting from cheaper commercial reagents, ambient reaction conditions, and minimal purification efforts.
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