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Ruthenium-catalyzed reaction of dinitriles with primary alcohols for the synthesis of N-alkylated cyclic β-enaminonitriles

文献类型： 外文期刊

作者： Ma, Wei 1 ; Zhao, Qiang 1 ; Su, Shibin 1 ; Zhang, Weiwei 1 ; Yao, Yao 1 ; Wang, Pei 1 ; Tang, Dong 2 ; Zhou, Pengjuan 2 ;

作者机构： 1.Ningxia Med Univ, Sch Basic Med Sci, Yinchuan 750004, Peoples R China

2.Ningxia Acad Agr & Forestry Sci, Inst Agr Resources & Environm, Yinchuan 750004, Peoples R China

关键词： N-alkylated cyclic beta-enaminonitriles; aliphatic dinitrile; primary alcohol; ruthenium-catalyzed

期刊名称：ASIAN JOURNAL OF ORGANIC CHEMISTRY （ 影响因子：2.7； 五年影响因子：2.6 ）

ISSN： 2193-5807

年卷期： 2025 年 14 卷 4 期

页码：

收录情况： SCI

摘要： A novel one-pot synthetic approach for preparing N-alkylated cyclic beta-enaminonitriles has been developed using readily available aliphatic dinitriles and primary alcohols. This method utilizes a Ru-MACHO complex catalyst (1 mol%) in conjunction with a strong base and a nonpolar solvent, exhibiting a broad substrate scope and excellent functional group tolerance. The process is highly atom economic, producing water as the sole by-produc. A range of N-alkylated cyclic beta-enaminonitriles were synthesized in good to excellent yields, and the method was successfully scaled up to gram-scale synthesis.

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