Fabrication of nanostructured multi-unit vehicle for intestinal-specific delivery and controlled release of peptide
文献类型： 外文期刊
作者： Feng, Kun 1 ; Li, Shu-Fang 1 ; Wei, Yun-Shan 1 ; Zong, Min-Hua 1 ; Hu, Teng-Gen 2 ; Wu, Hong 1 ; Han, Shuang-Yan 4 ;
作者机构： 1.South China Univ Technol, Sch Food Sci & Engn, Guangdong Prov Key Lab Green Proc Nat Prod & Prod, Guangzhou 510640, Peoples R China
2.Guangdong Acad Agr Sci, Sericultural & Agri Food Res Inst, Guangzhou, Peoples R China
3.Guangdong Key Lab Agr Prod Proc, Key Lab Funct Foods, Minist Agr, Guangzhou, Peoples R China
4.South China Univ Technol, Coll Biosci & Bioengn, Guangzhou 510640, Peoples R China
关键词： multi-unit vehicle; chitosan; high deacetylation degree; sodium alginate; intestinal-specific delivery; controlled release
期刊名称：NANOTECHNOLOGY （ 影响因子：3.551； 五年影响因子：3.392 ）
ISSN： 0957-4484
年卷期： 2021 年 32 卷 24 期
页码：
收录情况： SCI
摘要： An oral multi-unit delivery system was developed by incorporating the nanoparticle (NP) into the nanofiber mat and its efficiency for intestinal-specific delivery and controlled release of a peptide (insulin) was investigated. Initially, the influence of deacetylation degree (DD) of chitosan and ionic gelation methods on the properties of NPs was studied. High DD (95%) chitosan was attributed to higher encapsulation efficiency and stability when crosslinked with polyanion tripolyphosphate. Subsequently, the multi-unit system was fabricated using a pH-sensitive polymer (sodium alginate) as the coating layer to further encapsulate the NP. Fiber mat with an average diameter of 481 47 nm could significantly decrease the burst release of insulin in acidic condition and release most amount of insulin (>60%) in the simulated intestinal medium. Furthermore, the encapsulated peptide remained in good integrity. This multi-unit carrier provides the better-designed vehicle for intestinal-specific delivery and controlled release of the peptide.
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