文献类型： 外文期刊
作者： Niu, Yinjie 1 ; Su, Shibo 1 ; Chen, Xiaohan 1 ; Zhao, Lili 1 ; Chen, Hongyan 1 ;
作者机构： 1.Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, Heilongjiang Prov Key Lab,Lab Anim & Comparat Med, 678 Haping Rd, Harbin 150069, Peoples R China
2.Chinese Acad Fishery Sci, Pearl River Fisheries Res Inst, Key Lab Aquat Anim Immune Technol, Key Lab Fishery Drug Dev,Minist Agr & Rural Affai, Guangzhou 510380, Guangdong, Peoples R China
关键词： DPV CSC; Duck; Attenuation; Immune-related genes; Virulence; Passaging
期刊名称：VIRUS RESEARCH （ 影响因子：2.934； 五年影响因子：2.775 ）
ISSN： 0168-1702
年卷期： 2021 年 295 卷
页码：
收录情况： SCI
摘要： To better understand the pathogenicity of duck plague virus (DPV). The DPV Chinese standard challenge strain (DPV CSC) was continuously passaged 20 times in duck embryo fibroblasts (DEFs). DPV F1 was lethal for 2-week ducks, but DPV F10 and F20 were not lethal for 2-week ducks, the 528 bp in UL2 region of DPV F1-F20 was deleted, which suggested that the deletion in UL2 region was not related with the virulence of DPV. Compared with DPV F20 infected ducks, IL-8 in DPV F1 infected ducks was significantly upregulated, but IL-1, IL-2,IFN? and MHC-II were significantly downregulated. ISKNV copies in DPV F10 and F20 infected ducks were lower than the DPV F1 infected ducks. These results showed that massive viruses replication, upregulation of IL-8 expresssion, repression of IL-1, IL-2, IFN? and MHC-II expression resulted in serious lesions and high mortality. This study provided a in-depth understanding of the immune-related genes expression in the different virulence of DPV.
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