Determination of Pharmacokinetic and Pharmacokinetic-Pharmacodynamic Parameters of Doxycycline against Edwardsiella ictaluri in Yellow Catfish (Pelteobagrus fulvidraco)
文献类型： 外文期刊
作者： Xu, Ning 1 ; Li, Miao 2 ; Ai, Xiaohui 1 ; Lin, Zhoumeng 2 ;
作者机构： 1.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Wuhan 430223, Peoples R China
2.Kansas State Univ, Dept Anat & Physiol, Coll Vet Med, Inst Computat Comparat Med ICCM, Manhattan, KS 66506 USA
3.Hu Bei Prov Engn & Technol Res Ctr Aquat Prod Qua, Wuhan 430223, Peoples R China
4.Minist Agr & Rural Affairs, Control Qual & Safety Aquat Prod, Key Lab, Beijing 100141, Peoples R China
关键词： doxycycline; pharmacokinetics; pharmacokinetic-pharmacodynamic (PK/PD) parameters; Edwardsiella ictaluri; yellow catfish
期刊名称：ANTIBIOTICS-BASEL （ 影响因子：3.893； ）
ISSN： 2079-6382
年卷期： 2021 年 10 卷 3 期
页码：
收录情况： SCI
摘要： This study aimed to examine the pharmacokinetics of doxycycline (DC) in yellow catfish (Pelteobagrus fulvidraco) and to calculate related pharmacokinetic-pharmacodynamic (PK/PD) parameters of DC against Edwardsiella ictaluri. The minimum inhibitory concentration of DC against E. ictaluri was determined to be 500 mu g/L. As the increase of oral dose from 10 to 40 mg/kg, the area under the concentration vs. time curve from 0 to 96 h (AUC(0-96)) values were considerably increased in gill, kidney, muscle and skin, and plasma, except in liver. C-max values exhibited a similar dose-dependent increase trend in plasma and tissues except in liver, but other PK parameters had no apparent dose-dependence. The PK/PD parameter of the ratio of AUC(0-96) to minimum inhibitory concentration (AUC(0-96h)/MIC) was markedly increased in plasma and tissues dose-dependently except in liver, but %T > MIC values were increased only moderately at some dose groups. After receiving the same dose with disparate time intervals from 96 to 12 h, the AUC(0-96h)/MIC was distinctly increased in plasma and tissues, but the %T > MIC had a decreasing trend. When administering 20 mg/kg with a time interval of 96 h, the AUC(0-96h)/MIC values were consistently >173.03 h and the %T > MIC values were above 99.47% in plasma and all tissues. These results suggest that administration of DC at 20 mg/kg every 96 h is a preferable regimen in yellow catfish.
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