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Molecular epidemiology and genetic evolution of canine parvovirus in East China, during 2018-2020

文献类型： 外文期刊

作者： Chen, Yanzong 1 ; Wang, Jingyu 1 ; Bi, Zhenwei 1 ; Tan, Yeping 1 ; Lv, Lixin 1 ; Zhao, Hang 1 ; Xia, Xingxia 1 ; Zhu, Yum 1 ;

作者机构： 1.Jiangsu Acad Agr Sci, Inst Vet Med, Nanjing 210014, Peoples R China

2.Minist Agr, Key Lab Vet Bioprod Engn, Nanjing 210014, Peoples R China

关键词： Canine parvovirus; VP2 gene; Genetic diversity; Molecular epidemiology; Asian CPV-2c strain

期刊名称：INFECTION GENETICS AND EVOLUTION （ 影响因子：2.773； 五年影响因子：2.72 ）

ISSN： 1567-1348

年卷期： 2021 年 90 卷

页码：

收录情况： SCI

摘要： Canine parvovirus type 2 (CPV-2) emerged in the late 1970s, which caused high rates of morbidity and mortality in dogs. In last decade, five genetic variants (CPV-2a, CPV-2b, CPV-2c, New CPV-2a, and New CPV-2b) were frequently reported in the dog population, and replaced the original CPV-2, rising widespread concerns. However, little is known about their recent genetic diversity and evolution. The aim of this study was to analyze the characteristics of the CPV-2 strains collected in East China from 2018 to 2020. The 57 CPV-2 strains were isolated from rectal swab samples (n=140). They belong to three different genotypes, based on VP2 protein amino acid sequence. The results revealed a high prevalence of CPV-2c (77.19%) compared to the New CPV-2a (5.26%) and New CPV-2b (17.54%) strains. Further analysis showed that nucleotide homology of the VP2 gene among the 57 CPV strains was 98.9%-100%, and the homology with 24 reference strains from different countries and regions was 98.1%-100%. The phylogenetic tree of VP2 gene sequence showed that 44 CPV-2c strains were distantly related to CPV-2, CPV-2a, CPV-2b, New CPV-2a, New CPV-2b and European/American CPV-2c strains, and were closely related to Asian CPV-2c strains. The results showed that these Asian CPV-2c strains had become the dominant strain, which renewed the knowledge of CPV-2 molecular epidemiology in East China.

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