An overview of aflatoxin B1 biotransformation and aflatoxin M1 secretion in lactating dairy cows
文献类型： 外文期刊
作者： Min, Li 1 ; Fink-Gremmels, Johanna 2 ; Li, Dagang 1 ; Tong, Xiong 1 ; Tang, Jing 3 ; Nan, Xuemei 3 ; Yu, Zhongtang 4 ; Ch 1 ;
作者机构： 1.Guangdong Acad Agr Sci, Inst Anim Sci, State Key Lab Livestock & Poultry Breeding,Guangd, Minist Agr,Key Lab Anim Nutr & Feed Sci South Chi, Guangzhou, Peoples R China
2.Univ Utrecht, Inst Risk Assessment Sci, Utrecht, Netherlands
3.Chinese Acad Agr Sci, Inst Anim Sci, State Key Lab Anim Nutr, Beijing, Peoples R China
4.Ohio State Univ, Dept Anim Sci, Columbus, OH 43210 USA
关键词： Aflatoxin B1; Biotransformation; Aflatoxin M1; Dairy cow; Milk safety
期刊名称：ANIMAL NUTRITION （ 影响因子：4.492； ）
ISSN： 2405-6383
年卷期： 2021 年 7 卷 1 期
页码：
收录情况： SCI
摘要： Milk is considered a perfect natural food for humans and animals. However, aflatoxin B1 (AFB1) contaminating the feeds fed to lactating dairy cows can introduce aflatoxin M1 (AFM1), the main toxic metabolite of aflatoxins into the milk, consequently posing a risk to human health. As a result of AFM1 monitoring in raw milk worldwide, it is evident that high AFM1 concentrations exist in raw milk in many countries. Thus, the incidence of AFM1 in milk from dairy cows should not be underestimated. To further optimize the intervention strategies, it is necessary to better understand the metabolism of AFB1 and its biotransformation into AFM1 and the specific secretion pathways in lactating dairy cows. The metabolism of AFB1 and its biotransformation into AFM1 in lactating dairy cows are drawn in this review. Furthermore, recent data provide evidence that in the mammary tissue of lactating dairy cows, aflatoxins significantly increase the activity of a protein, ATP-binding cassette super-family G member 2 (ABCG2), an efflux transporter known to facilitate the excretion of various xenobiotics and veterinary drugs into milk. Further research should focus on identifying and understanding the factors that affect the expression of ABCG2 in the mammary gland of cows. (C) 2021, Chinese Association of Animal Science and Veterinary Medicine. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.
- 相关文献
作者其他论文 更多>>
-
The highly allo-autopolyploid modern sugarcane genome and very recent allopolyploidization in Saccharum
作者：Zhang, Jisen;Hua, Xiuting;Wang, Baiyu;Yu, Zehuai;Gao, Ruiting;Wang, Tianyou;Zhang, Qing;Li, Zhen;Li, Yihan;Xu, Yi;Yao, Wei;Zhang, Muqing;Chen, Baoshan;Qi, Yiying;Wang, Yongjun;Wang, Yuhao;Li, Shuangyu;Qi, Nameng;Feng, Xiaoxi;Wu, Mingxing;Du, Cuicui;Deng, Zuhu;Qi, Yongwen;Huang, Yumin;Zhang, Yixing;Mei, Jing;Pan, Haoran;Liu, Jia;Chen, Shuqi;Fang, Yaxue;Ma, Panpan;Sun, Yuanchang;Ming, Ray;Tang, Haibao;Wang, Gang;Li, Qingyun;Feng, Xiaomin;Liu, Xinlong;Wang, Jianping
关键词：
-
α-Glycerol Monolaurate Promotes Tight Junction Assembly and Enhances Epithelial Barrier Function in IPEC-J2 Cells and Partridge Chicks
作者：Dai, Siyu;Meng, Shuai;Liu, Shifeng;Wang, Hong;Li, Dagang
关键词：CaSR/PLC/IP3/AMPK signaling pathway; intestinal epithelia; tight junction assembly; alpha-glycerol monolaurate
-
Development of SYBR green I-based real-time qPCR differential diagnosis assays for porcine reproductive and respiratory syndrome virus typing in Guangdong province
作者：Ren, Zhaowen;Kang, Pu;Zhang, Pian;Chen, Jing;Xiang, Hua;Luo, Shengjun;Cai, Rujian;Huang, Yuan;Wang, Gang;Wang, Xiaohu;Ren, Zhaowen;Wang, Xiaohu;Kang, Pu;Sun, Chenglong;Jin, Yuzhu
关键词：PRRSV; duplex real-time PCR; prevalence; phylogenetic analysis; differential diagnosis
-
Prevalence of hepatitis E virus in swine in China: a systematic review with meta-analysis (2004-2023)
作者：He, Zhenwen;Liu, Dingyu;Liu, Baoling;Zhang, Pian;Wang, Xiaohu;Wang, Gang;Huang, Yuan;Chen, Jing;Cai, Rujian;He, Zhenwen;Liu, Dingyu;Liu, Baoling;Zhang, Pian;Wang, Xiaohu;Wang, Gang;Huang, Yuan;Chen, Jing;Cai, Rujian;He, Zhenwen;He, Zhenwen;Liu, Dingyu
关键词：hepatitis E virus; swine; China; prevalence; meta-analysis; systematic review; China swine hepatitis; epidemiological studies
-
Co-infection with Proteus mirabilis and extraintestinal pathogenic Escherichia coli aggravated liver injury in chickens by disrupting the jejunal barrier
作者：Cen, Jin-qi;Yang, Zhe;Liu, Xiao-li;Wang, Nan-lin;Wu, Si-yi;Zhang, Nan;Wang, Jingjing;Yu, Zhongjia;Min, Li;Zhou, Yuanyuan
关键词：Chicken; APEC Proteus mirabilis; Liver injury; Gut barrier
-
Detection and Comparison of Sow Serum Samples from Herds Regularly Mass Vaccinated with Porcine Reproductive and Respiratory Syndrome Modified Live Virus Using Four Commercial Enzyme-Linked Immunosorbent Assays and Neutralizing Tests
作者：Li, Chaosi;Fang, Shuhe;Fan, Aihua;Chen, Kai;Li, Chaosi;Liu, Zhicheng;Zhang, Jianfeng;Wang, Gang
关键词：porcine reproductive and respiratory syndrome virus; enzyme-linked immunosorbent assay; neutralizing antibodies; mass vaccination; modified live virus
-
Immune Protection Gap Between Porcine Reproductive and Respiratory Syndrome Subunit Vaccine (N Protein) and Live Vaccine
作者：Zhao, Mengpo;Zhang, Pian;Zhang, Xiaoxiao;Luo, Shengjun;Huang, Yanju;Wang, Gang;Xiang, Hua;Huang, Yuan;Chen, Jing;Wang, Xiaohu;Zhao, Mengpo;Yuan, Ziguo;Huang, Yanju;Wang, Xiaohu;Jin, Yuzhu
关键词：porcine peproductive and pespiratory syndrome virus; subunit vaccine; live vaccine; immune protection
