Antibacterial p-Terphenyl with a Rare 2,2 '-Bithiazole Substructure and Related Compounds Isolated from the Marine-Derived Actinomycete Nocardiopsis sp. HDN154086
文献类型： 外文期刊
作者： Chang, Yimin 1 ; Che, Qian 1 ; Xing, Li 1 ; Ma, Chuanteng 1 ; Han, Yaxin 1 ; Zhu, Tianjiao 1 ; Pfeifer, Blaine A. 2 ; Pen 1 ;
作者机构： 1.Ocean Univ China, Sch Med & Pharm, Qingdao 266003, Peoples R China
2.SUNY Buffalo, Dept Chem & Biol Engn, Buffalo, NY 14260 USA
3.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Key Lab Testing & Evaluat Aquat Prod Safety & Qua, Minist Agr & Rural Affairs, Qingdao 266071, Peoples R China
4.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266237, Peoples R China
期刊名称：JOURNAL OF NATURAL PRODUCTS （ 影响因子：3.779； 五年影响因子：3.989 ）
ISSN： 0163-3864
年卷期： 2021 年 84 卷 4 期
页码：
收录情况： SCI
摘要： Assisted by MS/MS-based molecular networking and X-ray diffraction analysis, five new p-terphenyl derivatives, namely, nocarterphenyls D-H (1-5), were obtained and characterized from the cultures of the marine sediment-derived actinomycete Nocardiopsis sp. HDN154086. The skeleton of nocarterphenyl D (1) was defined to possess a rare 2,2'-bithiazole scaffold, naturally occurring for the first time, and nocarterphenyls E-H (2-5) are p-terphenylquinones with unusual thioether linked fatty acid methyl ester substitutions. Compound 1 showed promising activity against multiple bacteria with MIC values ranging from 1.5 to 6.2 mu M, and 2 exhibited notable antibacterial activity against MRSA which surpassed the positive control ciprofloxacin.
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