Gefitinib inhibits infectious spleen and kidney necrosis virus infection in vivo and vitro by blocking virus endocytosis
文献类型： 外文期刊
作者： Niu, Yinjie 1 ; Fu, Xiaozhe 1 ; Lin, Qiang 1 ; Liu, Lihui 1 ; Luo, Xia 1 ; Liang, Hongru 1 ; Li, Ningqiu 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Pearl River Fisheries Res Inst, Key Lab Fishery Drug Dev, Minist Agr & Rural Affairs,Key Lab Aquat Anim Imm, Guangzhou 510380, Guangdong, Peoples R China
关键词： Infectious spleen and kidney necrosis virus; Gefitinib; Inhibition; EGFR/PI3K signaling
期刊名称：AQUACULTURE （ 影响因子：3.224； 五年影响因子：3.591 ）
ISSN： 0044-8486
年卷期： 2021 年 539 卷
页码：
收录情况： SCI
摘要： Infectious spleen and kidney necrosis virus disease (ISKNVD) caused significant economic losses to the fishery industry. So it is urgent to develop an effective measure for prevention ISKNVD. In this study, we investigated the effects of gefitinib against ISKNV in vitro and vivo. The gefitinib inhibited viral protein synthesis and decreased viral titers with the dose-dependent manner in Chinese perch brain cells (CPB) cells. Gefitinib was observed to inhibit ISKNV infection by blocking ISKNV entry into CPB cells. Interestingly, gefitinib inhibited EGFR/PI3K phosphorylation and suppressed microfilament gathering induced by ISKNV. At the same time, gefitinib inhibited ISKNV infection and decreased pathogenicity of ISKNV in vivo. These results suggested that gefitinib prevented ISKNV infection by blocking virus-mediated endocytosis. This research provided potential of gefitinib for preventing ISKNVD.
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