Protective effects of protocatechuic acid on growth performance, intestinal barrier and antioxidant capacity in broilers challenged with lipopolysaccharide
文献类型： 外文期刊
作者： Jiang, S. Q. 1 ; Chen, Z. L. 1 ; Zhang, S. 1 ; Ye, J. L. 1 ; Wang, Y. B. 1 ;
作者机构： 1.Guangdong Acad Agr Sci, Inst Anim Sci, State Key Lab Livestock & Poultry Breeding, Key Lab Anim Nutr & Feed Sci South China,Minist Ag, Guangzhou 510640, Peoples R China
关键词： Antioxidant effect; Feed additive; Intestinal morphology; Lipopolysaccharide challenge; Yellow feather broiler
期刊名称：ANIMAL （ 影响因子：3.6； 五年影响因子：3.7 ）
ISSN： 1751-7311
年卷期： 2023 年 17 卷 1 期
页码：
收录情况： SCI
摘要： 'Prohibition of the antibiotic uses' aggravates the problem of intestinal diseases in poultry, and nutritional regulation has become a research hotspot, such as supplementation with active ingredients derived from plants. This research was conducted to investigate the effects of protocatechuic acid (PCA) on growth, intestinal barrier, and antioxidant capacity of broilers injected with lipopolysaccharide (LPS). Four hun-dred and eighty 1-day-old yellow feather broilers were randomly allocated to four groups, each with six replicates of 20 broilers. The treatments were basal diet + saline injection (CON) or LPS injection (CON-LPS), and diets with 300 or 600 mg/kg PCA supplementation + LPS injection (P300, P600). Birds were injected intramuscularly on 17th and 19th day of age, then sampled on day 21. The LPS injection signif-icantly decreased BW and average daily gain of broilers, and compared with birds in CON-LPS, PCA sup-plementation increased (P < 0.05) those variables; moreover, 300 mg/kg PCA also decreased the feed-to -gain ratio. No differences were observed in relative weights of immune organs (P > 0.05). LPS decreased the villus height/crypt depth ratio (V/C) in jejunum of broilers, while PCA (P300 and P600) increased (P < 0.05) the jejunal villus height and V/C compared with birds in CON-LPS. LPS challenge increased jeju-nal malondialdehyde (MDA) concentration and decreased total superoxide dismutase (T-SOD) and glu-tathione peroxidase (GSH-Px) activities in plasma (P < 0.05); compared with birds in CON-LPS, jejunal and plasmal GSH-Px activity (P300 and P600) and jejunal T-SOD activity (P300) were decreased (P < 0.05), and hepatic MDA concentration (P600) was increased (P < 0.05). LPS significantly decreased the transcript abundances of OCLN, ZO-1, JAM2, MUC2, SOD1, CAT and GPX in jejunal mucosa of birds, and supplementation with PCA attenuated the decrease in OCLN, JAM2, and MUC2 expression compared with birds in CON-LPS; moreover, 600 mg/kg PCA offset the deduction in SOD1, CAT and GPX expression. In conclusion, dietary supplementation with PCA could improve antioxidant status and attenuate the damage in intestinal barrier and loss in growth performance of LPS-challenged broilers, and 600 mg/kg PCA showed more improved effects on antioxidant capacity.(c) 2022 The Authors. Published by Elsevier B.V. on behalf of The Animal Consortium. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
- 相关文献
作者其他论文 更多>>
-
Dietary isoleucine supplementation enhances growth performance, modulates the expression of genes related to amino acid transporters and protein metabolism, and gut microbiota in yellow-feathered chickens
作者：Ruan, D.;Fan, Q. L.;Zhang, S.;Lin, X. J.;Zheng, C. T.;Jiang, Z. Y.;Jiang, S. Q.;EI-Senousey, H. K.;Fouadt, A. M.;Yan, S. J.;Yan, S. J.
关键词：isoleucine; yellow -feathered chickens; amino acid transporters; protein metabolism; gut microbiota
-
Modelling nitrogen-corrected apparent metabolisable energy requirement for egg production of 3 BW types of Yellow Broiler breeder hens during the egg-laying period
作者：Gou, Z.;Jiang, Z.;Zhang, S.;Lin, X.;Wang, Y.;Ruan, D.;Fan, Q.;Ye, J.;Mao, S.;Jiang, S.
关键词：Factorial approach; Maintenance; Gompertz; Body weight; Validation
-
Dietary requirements of sodium and chloride for slow-growing broiler breeds during finisher phase of production
作者：Yu, H.;Wang, Y. B.;Lin, X. J.;Jiang, S. Q.;Yu, H.;Azzam, M. M.;Alqhtani, A. H.;Al-Abdullatif, A. A.;Alhidary, I. A.
关键词：chickens; sodium requirement; chloride requirement; growth performance; meat quality
-
Effects and interaction of dietary calcium and non-phytate phosphorus for slow-growing yellow-feathered broilers during the starter phase
作者：Wang, Y. B.;Wang, W. W.;Fan, Q. L.;Ye, J. L.;Zhang, S.;Jiang, S. Q.;Wang, W. W.
关键词：Alkaline phosphatase; Bone; Dietary nutrient levels; Performance; Tibial characteristics
-
Dietary L-arginine supplementation enhances growth performance, intestinal antioxidative capacity, immunity and modulates gut microbiota in yellow-feathered chickens
作者：Ruan, D.;Fouad, A. M.;Fan, Q. L.;Huo, X. H.;Zhang, C.;Zhang, J. H.;Jiang, S. Q.;Fouad, A. M.;Kuang, Z. X.;Wang, H.;Guo, C. Y.;Deng, Y. F.
关键词：arginine; intestinal antioxidation; immunity; gut microbiota; yellow-feathered chicken
-
Alterations of the fatty acid composition and lipid metabolome of breast muscle in chickens exposed to dietary mixed edible oils
作者：Cui, X. Y.;Gou, Z. Y.;Abouelezz, K. F. M.;Li, L.;Lin, X. J.;Fan, Q. L.;Wang, Y. B.;Cheng, Z. G.;Ding, F. Y.;Jiang, S. Q.;Abouelezz, K. F. M.
关键词：Qingyuan chickens; coconut oil; growth performance; n-3 fatty acids; phospholipids
-
Effects of dietary incorporation of linseed oil with soybean isoflavone on fatty acid profiles and lipid metabolism-related gene expression in breast muscle of chickens
作者：Gou, Z. Y.;Cui, X. Y.;Li, L.;Fan, Q. L.;Lin, X. J.;Wang, Y. B.;Jiang, Z. Y.;Jiang, S. Q.
关键词：growth performance; n-3 polyunsaturated fatty acid; meat quality; antioxidation; health indicator
