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Concurrence of Inactivation Enzyme-Encoding Genes tet(X), blaEBR, and estT in Empedobacter Species from Chickens and Surrounding Environments

文献类型： 外文期刊

作者： Chen, Chong 1 ; Lv, Yilin 1 ; Wu, Taotao 1 ; Liu, Jing 1 ; Guo, Yanan 4 ; Huang, Jinlin 1 ;

作者机构： 1.Yangzhou Univ, Inst Agr Sci & Technol Dev, Joint Int Res Lab Agr & Agriprod Safety, Minist Educ China, Yangzhou 225009, Peoples R China

2.Yangzhou Univ, Jiangsu Coinnovat Ctr Prevent & Control Important, Jiangsu Key Lab Zoonosis, Yangzhou 225009, Peoples R China

3.Yangzhou Univ, Key Lab Prevent & Control Biol Hazard Factors Anim, Minist Agr China, Yangzhou 225009, Peoples R China

4.Ningxia Acad Agr & Forestry Sci, Anim Sci Inst, Yinchuan 750002, Peoples R China

关键词： Empedobacter sp.; chicken; tetracyclines; tet(X); beta-lactams; bla (EBR); macrolides; estT; ISCR2

期刊名称：FOODS （ 影响因子：5.1； 五年影响因子：5.6 ）

ISSN：

年卷期： 2024 年 13 卷 19 期

页码：

收录情况： SCI

摘要： The emergence of inactivation enzyme-encoding genes tet(X), bla(EBR), and estT challenges the effectiveness of tetracyclines, beta-lactams, and macrolides. This study aims to explore the concurrence and polymorphism of their variants in Empedobacter sp. strains from food-producing animals and surrounding environments. A total of eight tet(X) variants, seven bla(EBR) variants, and seven estT variants were detected in tet(X)-positive Empedobacter sp. strains (6.7%) from chickens, sewage, and soil, including 31 Empedobacter stercoris and 6 novel species of Taxon 1. All of them were resistant to tigecycline, tetracycline, colistin, and ciprofloxacin, and 16.2% were resistant to meropenem, florfenicol, and cefotaxime. The MIC90 of tylosin, tilmicosin, and tildipirosin was 128 mg/L, 16 mg/L, and 8 mg/L, respectively. Cloning expression confirmed that tet(X6) and the novel variants tet(X23), tet(X24), tet(X25), tet(X26), and tet(X26.2) conferred high-level tigecycline resistance, while all of the others exhibited relatively low-level activities or were inactivated. The bacterial relationship was diverse, but the genetic environments of tet(X) and bla(EBR) were more conserved than estT. An ISCR2-mediated tet(X6) transposition structure, homologous to those of Acinetobacter sp., Proteus sp., and Providencia sp., was also identified in Taxon 1. Therefore, the tet(X)-positive Empedobacter sp. strains may be ignored and pose a serious threat to food safety and public health.

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