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Identification, in silico selection, and mechanistic investigation of antioxidant peptides from corn gluten meal hydrolysate

文献类型： 外文期刊

作者： Wang, Xiao 1 ; Fu, Juan 1 ; Bhullar, Khushwant S. 3 ; Chen, Bingjie 1 ; Liu, Hongru 1 ; Zhang, Yi 1 ; Wang, Chunfang 1 ; Liu, Chenxia 1 ; Su, Di 4 ; Ma, Xia 2 ; Qiao, Yongjin 1 ;

作者机构： 1.Shanghai Acad Agr Sci, Res Ctr Agr Prod Preservat & Proc, Crop Breeding & Cultivat Res Inst, Shanghai, Peoples R China

2.Shanghai Inst Technol, Sch Flavor & Fragrance Technol & Engn, Shanghai, Peoples R China

3.Univ Alberta, Dept Agr Food & Nutr Sci, Edmonton, AB T6G 2P5, Canada

4.Shanghai Jiao Tong Univ, Sch Pharm, 800 Dongchuan Rd, Shanghai 200240, Peoples R China

关键词： Corn gluten meal; Antioxidant activity; Identification; In silico selection; Quantum chemistry

期刊名称：FOOD CHEMISTRY （ 影响因子：8.8； 五年影响因子：8.6 ）

ISSN： 0308-8146

年卷期： 2024 年 446 卷

页码：

收录情况： SCI

摘要： Seven novel antioxidant peptides (AWF, LWQ, WIY, YLW, LAYW, LPWG, and LYFY) exhibiting a superior activity compared to trolox were identified through in silico screening. Among these, the four peptides (WIY, YLW, LAYW, and LYFY) displayed notably enhanced performance, with ABTS activity 2.58-3.26 times and ORAC activity 5.19-8.63 times higher than trolox. Quantum chemical calculations revealed that the phenolic hydroxyl group in tyrosine and the nitrogen-hydrogen bond in the indole ring of tryptophan serve as the critical sites for antioxidant activity. These findings likely account for the potent chemical antioxidant activity. The corn peptides also exerted a protective effect against AAPH-induced cytomorphologic changes in human erythrocytes by modulating the antioxidant system. Notably, LAYW exhibited the most pronounced cytoprotective effects, potentially due to its high content of hydrophobic amino acids.

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