Genistein Inhibits the Pathogenesis of Aeromonas hydrophila by Disrupting Quorum Sensing Mediated Biofilm Formation and Aerolysin Production
文献类型： 外文期刊
作者： Dong, Jing 1 ; Zhang, Defu 2 ; Li, Jianrong 2 ; Liu, Yongtao 1 ; Zhou, Shun 1 ; Yang, Yibin 1 ; Xu, Ning 1 ; Yang, Qiuhon 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Wuhan, Peoples R China
2.Bohai Univ, Coll Food Sci & Engn, Jinzhou, Peoples R China
关键词： Aeromonas hydrophila; quorum sensing; genistein; anti-virulence; natural compound
期刊名称：FRONTIERS IN PHARMACOLOGY （ 影响因子：5.811； 五年影响因子：6.006 ）
ISSN：
年卷期： 2021 年 12 卷
页码：
收录情况： SCI
摘要： Aeromonas hydrophila is an opportunistic pathogen that is responsible for a variety of infectious diseases both in human and animals, particularly aquatic animals. Moreover, the pathogen has become a foodborne pathogen by transmitting from seafood to human. The abuse of antibiotics in aquaculture results in the emergence of antibiotic resistance and treatment failure. Therefore, novel approaches are urgently needed for managing resistant A. hydrophila associated infections. Aerolysin, an essential virulence factor of pathogenic A. hydrophila strain, has been identified as target developing novel drugs against pathogenesis of A. hydrophila. In the present study, genistein, without anti-A. hydrophila activity, was identified that could decrease the production of aerolysin and biofilm formation at a dose-dependent manner. Transcription of aerolysin encoding gene aerA and quorum sensing related genes ahyI and ahyR was significantly down-regulated when co-cultured with genistein. Cell viability studies demonstrated that genistein could significantly improve aerolysin mediated A549 cell injury. Furthermore, genistein could provide a remarkable protection to channel catfish infected with A. hydrophila. These findings indicate that targeting quorum sensing and virulence can be a useful approach developing drugs against A. hydrophila infections in aquaculture. Moreover, genistein can be chosen as a promising candidate in developing drugs against A. hydrophila.
- 相关文献
作者其他论文 更多>>
-
Molecular mechanism of Yersinia ruckeri Flagellin C (FliC) induced intestinal inflammation in channel catfish ( Ictalurus punctatus)
作者：Yang, Yibin;He, Hao;Ai, Xiaohui;Zhu, Xia;Huang, Yucong;Yin, Fei;Xu, Jingen;Chen, Yuhua
关键词：Channel catfish; Yersinia ruckeri; Virulence; Intestinal inflammation; Molecular mechanism
-
Characteristics and functions of interleukin 21 in channel catfish (Ictalurus punctatus)
作者：He, Hao;He, Hao;Zhu, Xia;Dong, Jing;Yang, Qiuhong;Ai, Xiaohui;Yang, Yibin;Deng, Ping;Huang, Yucong;Wang, Hui
关键词：Channel catfish; IL-21; Immune response; Inflammatory factors; Gene expression
-
Population Pharmacokinetics of Enrofloxacin in Ctenopharyngodon idella Based on the Sparse Sampling Method and a Nonlinear Mixed Effect Model Following Intravenous and Oral Administration
作者：Xu, Ning;Zhang, Huan;Zhou, Shun;Liu, Yongtao;Yang, Qiuhong;Dong, Jing;Ai, Xiaohui;Xu, Ning;Zhou, Shun;Liu, Yongtao;Yang, Qiuhong;Dong, Jing;Ai, Xiaohui;Zhang, Huan;Ding, Yongzhen
关键词：bioavailability; enrofloxacin; grass carp; population pharmacokinetics
-
Identification and biological characterization of the pathogen responsible for acute haemorrhagic disease in largemouth bass
作者：Yang, Yibin;He, Hao;Yang, Qiuhong;Ai, Xiaohui;Zhu, Xia;Deng, Ping
关键词：Streptococcus iniae; Largemouth bass; Whole genome; Virulence; Drug resistance
-
Population Pharmacokinetics of Enrofloxacin in Micropterus salmoides Based on a Nonlinear Mixed Effect Model After Intravenous and Oral Administration
作者：Xu, Ning;Zhou, Shun;Dong, Jing;Li, Jiangtao;Ai, Xiaohui;Xu, Ning;Ding, Yongzhen
关键词：enrofloxacin; population pharmacokinetics; statistical approaches; largemouth bass; body weight
-
Preclinical Evaluation of Fenbendazole for Controlling Gyrodactylus kobayashii (Monogenea, Gyrodactylidae) in Goldfish: Dose Optimization and Safety Assessment
作者：Dong, Jing;Li, Jiangtao;Liu, Yongtao;Yang, Qiuhong;Xu, Ning;Ai, Xiaohui;Zhou, Shun;Dong, Jing
关键词：preclinical study; fenbendazole; monogenean; anthelmintic treatment; aquaculture
-
Novel Insights into the Therapeutic Effect of Amentoflavone Against Aeromonas hydrophila Infection by Blocking the Activity of Aerolysin
作者：Dong, Jing;Li, Shengping;Zhou, Shun;Liu, Yongtao;Yang, Qiuhong;Xu, Ning;Yang, Yibin;Ai, Xiaohui;Li, Shengping;Cheng, Bo
关键词：
Aeromonas hydrophila ; aerolysin; amentoflavone; molecular dynamics; anti-infective
