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A pectic polysaccharide from fresh okra (Abelmoschus esculentus L.) beneficially ameliorates CCl4-induced acute liver injury in mice by antioxidation, inhibition of inflammation and modulation of gut microbiota

文献类型： 外文期刊

作者： Yan, Jing-Kun 1 ; Wang, Chun 2 ; Chen, Ting -Ting 2 ; Zhu, Jie 1 ; Chen, Xu 1 ; Li, Longqing 1 ; Liu, Xiaozhen 1 ; Zhang, Henan 3 ; Li, Lin 1 ;

作者机构： 1.Dongguan Univ Technol, Engn Res Ctr Hlth Food Design & Nutr Regulat, Sch Life & Hlth Technol,China Natl Light Ind Key L, Dongguan Key Lab Typ Food Precis Design, Dongguan 523808, Peoples R China

2.Jiangsu Univ, Inst Food Phys Proc, Sch Food & Biol Engn, Zhenjiang 212013, Peoples R China

3.Shanghai Acad Agr Sci, Inst Edible Fungi, Natl Engn Res Ctr Edible Fungi,Minist Agr, Key Lab Edible Fungi Resources & Utilizat South, Shanghai 200000, Peoples R China

关键词： Pectic polysaccharide; Acute liver damage; Gut microbiota; Hepatoprotection; Abelmoschus esculentus (Linn; ) Moench

期刊名称：FOOD AND CHEMICAL TOXICOLOGY （ 影响因子：5.572； 五年影响因子：5.692 ）

ISSN： 0278-6915

年卷期： 2023 年 171 卷

页码：

收录情况： SCI

摘要： Okra [Abelmoschus esculentus (Linn.) Moench], as a well-known medicinal and food plant, has important phys-iological activities and health benefits, and polysaccharide is its main bioactive component. In this study, a pectic polysaccharide (OPS-50) prepared from fresh okra pods by three-phase partitioning and gradient (NH4)2SO4 precipitation at a saturation of 50% was employed in carbon tetrachloride (CCl4)-caused acute liver damage in mice to evaluate the hepatoprotective potential. Results indicated that OPS-50 was mainly composed of a limited linear homogalacturonan backbone and abundant rhamnogalacturonan-I domains as side chains. OPS-50 exerted positively protective effects on acute liver damage induced by CCl4 in mice through relieving weight reduction and organ damage, ameliorating liver function and dyslipidemia, alleviating oxidative stress, suppressing pro -inflammatory cytokines, modulating gut microbiota, and promoting short-chain fatty acid secretion. More-over, liver histopathology demonstrated the protective benefit of OPS-50 on CCl4-caused acute liver damage in mice. Therefore, our data suggested that the pectic OPS-50, as a dietary supplement, have great potential in preventing and treating chemical liver damages.

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