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SP-141 targets Trs85 to inhibit rice blast fungus infection and functions as a potential broad-spectrum antifungal agent

文献类型： 外文期刊

作者： Wu, Xi-Yu 1 ; Dong, Bo 2 ; Zhu, Xue-Ming 2 ; Cai, Ying-Ying 1 ; Li, Lin 2 ; Lu, Jian-Ping 5 ; Yu, Bin 6 ; Cheng, Jing-Li 6 ; Xu, Fei 2 ; Bao, Jian-Dong 2 ; Wang, Ying 7 ; Liu, Xiao-Hong 1 ; Lin, Fu-Cheng 1 ;

作者机构： 1.Zhejiang Univ, Inst Biotechnol, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou 310058, Zhejiang, Peoples R China

2.Zhejiang Acad Agr Sci, Inst Plant Protect & Microbiol, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou 310058, Zhejiang, Peoples R China

3.Univ Kentucky, Coll Med, Dept Pharmacol & Nutr Sci, Lexington, KY 40506 USA

4.Univ Kentucky, Coll Med, Markey Canc Ctr, Lexington, KY 40506 USA

5.Zhejiang Univ, Coll Life Sci, Hangzhou 310058, Zhejiang, Peoples R China

6.Zhejiang Univ, Inst Pesticide & Environm Toxicol, Minist Agr, Key Lab Mol Biol Crop Pathogens & Insects, Hangzhou 310058, Zhejiang, Peoples R China

7.Shanghai Acad Agr Sci, Inst Edible Fungi, Shanghai 201106, Peoples R China

关键词： Magnaporthe oryzae; rice blast; TRAPPIII complex; trs85; fungicide

期刊名称：PLANT COMMUNICATIONS （ 影响因子：10.5； 五年影响因子：10.5 ）

ISSN： 2590-3462

年卷期： 2024 年 5 卷 2 期

页码：

收录情况： SCI

摘要： Rice blast is a devastating disease worldwide, threatening rice production and food security. The blast fungus Magnaporthe oryzae invades the host via the appressorium, a specialized pressure -generating structure that generates enormous turgor pressure to penetrate the host cuticle. However, owing to ongoing evolution of fungicide resistance, it is vitally important to identify new targets and fungicides. Here, we show that Trs85, a subunit of the transport protein particle III complex, is essential for appressoriummediated infection in M. oryzae. We explain how Trs85 regulates autophagy through Ypt1 (a small guanosine triphosphatase protein) in M. oryzae. We then identify a key conserved amphipathic a helix within Trs85 that is associated with pathogenicity of M. oryzae. Through computer -aided screening, we identify a lead compound, SP -141, that affects autophagy and the Trs85-Ypt1 interaction. SP -141 demonstrates a substantial capacity to effectively inhibit infection caused by the rice blast fungus while also exhibiting wide-ranging potential as an antifungal agent with broad-spectrum activity. Taken together, our data show that Trs85 is a potential new target and that SP -141 has potential for the control of rice blast. Our findings thus provide a novel strategy that may help in the fight against rice blast.

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